Actively Recruiting

Phase 2
Age: 18Years - 75Years
All Genders
NCT07096843

A Phase 2 Study of Budoprutug in Subjects With Primary Membranous Nephropathy

Led by Climb Bio, Inc. · Updated on 2026-04-30

45

Participants Needed

45

Research Sites

109 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

To evaluate the safety and tolerability of three dose regimens of budoprutug in subjects with PMN

CONDITIONS

Official Title

A Phase 2 Study of Budoprutug in Subjects With Primary Membranous Nephropathy

Who Can Participate

Age: 18Years - 75Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Confirmed diagnosis of primary membranous nephropathy with positive anti-PLA2R antibodies
  • CD19+ B cell count of 40 cells/µL or higher
  • Urine protein-to-creatinine ratio of 2.0 g/g or higher
  • Estimated glomerular filtration rate (eGFR) of 35 mL/min/1.73 m² or higher
  • Stable treatment with RAAS inhibitors
  • Blood pressure below 150/90 mmHg at baseline
  • Adequate blood, liver, and kidney function
  • Willingness to use effective contraception (for both sexes)
  • Other inclusion criteria may apply
Not Eligible

You will not qualify if you...

  • Secondary membranous nephropathy
  • Rapidly progressive glomerulonephritis or other glomerulopathies
  • Prior B cell-depleting therapy within the last 24 weeks
  • Recent use of immunosuppressant drugs
  • Active infections or high risk of infection
  • History of cancer
  • Pregnancy or breastfeeding
  • Recent major surgery or hospitalization
  • Other exclusion criteria may apply

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 45 locations

1

Climb Bio Investigative Site #110

Denver, Colorado, United States, 80220

Actively Recruiting

2

Climb Bio Investigative Site #105

Orlando, Florida, United States, 32086

Actively Recruiting

3

Climb Bio Investigative Site #108

Atlanta, Georgia, United States, 30342

Actively Recruiting

4

Climb Bio Investigative Site #106

Indianapolis, Indiana, United States, 46268

Actively Recruiting

5

Climb Bio Investigative Site #101

Clifton Park, New York, United States, 12065

Actively Recruiting

6

Climb Bio Investigative Site #102

Philadelphia, Pennsylvania, United States, 19104

Not Yet Recruiting

7

Climb Bio Investigative Site #103

El Paso, Texas, United States, 79932

Actively Recruiting

8

Climb Bio Investigative Site #104

Sherman, Texas, United States, 75092

Actively Recruiting

9

Climb Bio Investigative Site# 602

Buenos Aires, Argentina, B1629

Actively Recruiting

10

Climb Bio Investigative Site# 603

Buenos Aires, Argentina, B1888

Actively Recruiting

11

Climb Bio Investigative Site #601

CABA, Argentina, C1111

Actively Recruiting

12

Climb Bio Investigative Site #604

CABA, Argentina, C1425

Actively Recruiting

13

Climb Bio Investigative Site #605

Córdoba, Argentina, C1425

Not Yet Recruiting

14

Climb Bio Investigative Site #606

Santa Fe, Argentina, S3000

Actively Recruiting

15

Climb Bio Investigative Site #502

Belo Horizonte, Brazil, 30150-320

Actively Recruiting

16

Climb Bio Investigative Site #505

Minas Gerais, Brazil, 36010-570

Actively Recruiting

17

Climb Bio Investigative Site #506

Pernambuco, Brazil, 50670-901

Not Yet Recruiting

18

Climb Bio Investigative Site #501

Porto Alegre, Brazil, 90020-090

Actively Recruiting

19

Climb Bio Investigative Site #503

São Paulo, Brazil, 05403-000

Actively Recruiting

20

Climb Bio Investigative Site #504

São Paulo, Brazil, 05403-000

Actively Recruiting

21

Climb Bio Investigative Site #701

Temuco, Araucania, Chile, 4811230

Not Yet Recruiting

22

Climb Bio Investigative Site #703

Valdivia, Los Ríos Region, Chile, 5020000

Not Yet Recruiting

23

Climb Bio Investigative Site #702

Santiago, Santiago Metropolitan, Chile, 8320165

Not Yet Recruiting

24

Climb Bio Investigative Site #403

Beijing, Changping District, China, 102218

Not Yet Recruiting

25

Climb Bio Investigative Site #401

Beijing, Cheng District, China, 100034

Not Yet Recruiting

26

Climb Bio Investigative Site #408

Shenzhen, Guangdong, China, 518036

Not Yet Recruiting

27

Climb Bio Investigative Site #402

Wuxi, Jiangsu, China, 214023

Not Yet Recruiting

28

Climb Bio Investigative Site #407

Xi'an, Shaanxi, China, 710061

Not Yet Recruiting

29

Climb Bio Investigative Site #405

Jinan, Shandong, China, 250014

Not Yet Recruiting

30

Climb Bio Investigative Site #409

Yantai, Shandong, China, 264000

Not Yet Recruiting

31

Climb Bio Investigative Site #404

Yibin, Sichuan, China, 644000

Not Yet Recruiting

32

Climb Bio Investigative Site #406

Beijing, Xicheng District, China, 100044

Not Yet Recruiting

33

Climb Bio Investigative Site #903

Tbilisi, Georgia, 0112

Actively Recruiting

34

Climb Bio Investigative Site #902

Tbilisi, Georgia, 0114

Actively Recruiting

35

Climb Bio Investigative Site #901

Tbilisi, Georgia, 0144

Actively Recruiting

36

Climb Bio Investigative Site #204

Taichung, Taiwan, 404

Actively Recruiting

37

Climb Bio Investigative Site# 202

Taipei, Taiwan, 100

Not Yet Recruiting

38

Climb Bio Investigative Site# 201

Taipei, Taiwan, 110

Actively Recruiting

39

Climb Bio Investigative Site #205

Taipei, Taiwan, 112

Actively Recruiting

40

Climb Bio Investigative Site# 203

Taipei, Taiwan, 235

Not Yet Recruiting

41

Climb Bio Investigative Site #803

Ivano-Frankivsk, Ukraine, 76008

Actively Recruiting

42

Climb Bio Investigative Site# 801

Kyiv, Ukraine, 02125

Actively Recruiting

43

Climb Bio Investigative Site #805

Kyiv, Ukraine, 03151

Actively Recruiting

44

Climb Bio Investigative Site #804

Rivne, Ukraine, 33027

Actively Recruiting

45

Climb Bio Investigative Site #802

Ternopil, Ukraine, 46002

Actively Recruiting

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Research Team

C

Climb Bio Study Director

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NON_RANDOMIZED

Model

SEQUENTIAL

Primary Purpose

TREATMENT

Number of Arms

3

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