Actively Recruiting
A Phase 2 Study of EIK1001 in Combo With Pembrolizumab and Chemotherapy in Patients With Stage 4 NSCLC
Led by Eikon Therapeutics · Updated on 2025-11-12
70
Participants Needed
39
Research Sites
199 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is for patients with advanced/metastatic non-small cells lung cancer (NSCLC) who have not received any treatment through the vein for the advanced disease.
CONDITIONS
Official Title
A Phase 2 Study of EIK1001 in Combo With Pembrolizumab and Chemotherapy in Patients With Stage 4 NSCLC
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Be 18 years of age or older at the time of consent
- Have confirmed stage 4 non-small cell lung cancer, either squamous or non-squamous type
- Have no tumor mutations or fusions that indicate need for mutation-directed therapy
- Have at least one measurable tumor lesion at baseline according to RECIST 1.1
- Have not received prior systemic treatment for advanced or metastatic NSCLC
- Have an Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 to 1
- Have adequate organ function as determined by study assessments
You will not qualify if you...
- Have NSCLC that is not predominantly squamous or non-squamous cell histology
- Have participated in another investigational agent study or received investigational therapy within 4 weeks or 5 half-lives before starting EIK1001
- Have received prior systemic therapy for metastatic disease or had major surgery less than 3 weeks before starting EIK1001
- Have completed palliative radiotherapy within 7 days before the first study drug dose
- Have a history of prior malignancy unless treated curatively with no recurrence for 5 years
- Have an active infection requiring treatment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 39 locations
1
Southern Cancer Care
Daphne, Alabama, United States, 36608
Actively Recruiting
2
Ironwood Cancer and Research Center
Chandler, Arizona, United States, 85224
Actively Recruiting
3
California Cancer Care Associates for Research & Excellence
Fresno, California, United States, 93720
Actively Recruiting
4
California Research Institute
Los Angeles, California, United States, 90027
Actively Recruiting
5
University of Southern California, Norris Comprehensive Cancer Center
Los Angeles, California, United States, 90033
Actively Recruiting
6
Providence St Joseph Hospital, Center for Cancer Prevention and Treatment
Orange, California, United States, 92868
Actively Recruiting
7
Sutter Health Institute for Medical Research
Sacramento, California, United States, 95816
Actively Recruiting
8
Rocky Mountain Cancer
Lone Tree, Colorado, United States, 80124
Actively Recruiting
9
Bioresearch Partner
Hialeah, Florida, United States, 33013
Actively Recruiting
10
Memorial Cancer Institute
Hollywood, Florida, United States, 33021
Actively Recruiting
11
Mid-Florida Hematology and Oncology Center
Orange, Florida, United States, 32763
Actively Recruiting
12
Orlando Health Cancer Institute
Orlando, Florida, United States, 32806
Actively Recruiting
13
Moffitt Cancer Center
Tampa, Florida, United States, 33612
Not Yet Recruiting
14
Atlanta Piedmont Hospital
Atlanta, Georgia, United States, 30318
Not Yet Recruiting
15
Kaiser Permanente Hawaii
Honolulu, Hawaii, United States, 96819
Actively Recruiting
16
Illinois Cancer Specialists
Niles, Illinois, United States, 60714
Actively Recruiting
17
Accelacare of Duly
Tinley Park, Illinois, United States, 60487
Actively Recruiting
18
Indiana University Cancer Center
Indianapolis, Indiana, United States, 46202
Actively Recruiting
19
Health Midwest Oncology Associates of Kansas
Overland Park, Kansas, United States, 66211
Actively Recruiting
20
Cancer Center of Kansas
Wichita, Kansas, United States, 67214
Actively Recruiting
21
Medstar Franklin Square Cancer Center at Loch Raven Campus
Baltimore, Maryland, United States, 21237
Actively Recruiting
22
Maryland Oncology
Columbia, Maryland, United States, 20144
Actively Recruiting
23
Jersey Shore University Medical Center/Meridian Hematology & Oncology
Neptune City, New Jersey, United States, 07753
Actively Recruiting
24
New York Cancer and Blood Specialists
Babylon, New York, United States, 11702
Actively Recruiting
25
Laura & Isaac Perlmutter Cancer Center at NYU Langone Health
New York, New York, United States, 10016
Actively Recruiting
26
Weil Cornell Medical Center
New York, New York, United States, 10022
Actively Recruiting
27
Albert Einstein College of Medicine, Jacobi Medical Center
The Bronx, New York, United States, 10461
Actively Recruiting
28
Cancer and Blood Specialists of New York, White Plains Hospital
White Plains, New York, United States, 10601
Actively Recruiting
29
Messino Cancer Centers
Asheville, North Carolina, United States, 28806
Actively Recruiting
30
Gabrail Cancer Center
Canton, Ohio, United States, 44718
Actively Recruiting
31
Willamette Valley
Eugene, Oregon, United States, 97401
Actively Recruiting
32
Tennessee Cancer Specialists
Knoxville, Tennessee, United States, 37909
Actively Recruiting
33
Baptist Cancer Center
Memphis, Tennessee, United States, 38120
Actively Recruiting
34
Texas Oncology, Austin
Austin, Texas, United States, 78745
Actively Recruiting
35
Texas Oncology, Bedford
Bedford, Texas, United States, 76022
Actively Recruiting
36
The Center for Cancer and Blood Disorders
Fort Worth, Texas, United States, 76104
Actively Recruiting
37
Blue Ridge Cancer Care Oncology Associates SW VA
Blacksburg, Virginia, United States, 24060
Actively Recruiting
38
Virginia Cancer Specialists
Fairfax, Virginia, United States, 22031
Actively Recruiting
39
Shenandoah Oncology
Winchester, Virginia, United States, 22601
Actively Recruiting
Research Team
G
Genevieve Doster
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here