Actively Recruiting
A Phase 1/2 Study to Investigate CRB-701 in Solid Tumors
Led by Corbus Pharmaceuticals Inc. · Updated on 2026-01-08
348
Participants Needed
41
Research Sites
147 weeks
Total Duration
On this page
Sponsors
C
Corbus Pharmaceuticals Inc.
Lead Sponsor
C
CSPC Zhongnuo Pharmaceutical (Shijiazhuang) Co., Ltd.
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to define a safe and effective dose of CRB-701 for participants with solid tumors that are expressing a protein called nectin-4. The main questions it aims to answer are: What is the the safe and effective dose of CRB-701? What cancers can be treated effectively with CRB-701? Participants will be asked to attend clinic and be given a intravenous infusion of CRB-701. They will have blood tests, CT or MRI Scans, and other assessments to measure whether CRB-701 has an effect on tumors.
CONDITIONS
Official Title
A Phase 1/2 Study to Investigate CRB-701 in Solid Tumors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Confirmed diagnosis of select advanced or metastatic nectin-4 expressing solid tumors that have progressed after all appropriate therapies or have no standard therapy with proven benefit
- For Part C, HNSCC participants may enroll as first-line therapy
You will not qualify if you...
- Active or uncontrolled CNS metastases
- History of solid tumors other than the diseases under study
- History of and/or current cardiovascular events or conditions in the previous 6 months
- Pre-existing Grade 2 or higher neuropathy
- Hemoglobin A1C 8% or higher, uncontrolled diabetes mellitus, or known diabetic neuropathy
- Active ocular disease at baseline
- Chronic severe liver disease or liver cirrhosis
- Interstitial lung disease or pneumonitis within 6 months before starting treatment
- Other significant comorbidities
AI-Screening
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Trial Site Locations
Total: 41 locations
1
O'Neal Comprehensive Cancer Center at University of Alabama-Birmingham
Birmingham, Alabama, United States, 35294
Actively Recruiting
2
City of Hope Cancer Center
Duarte, California, United States, 91010
Actively Recruiting
3
Moores Cancer Centre at UC San Diego Health
San Diego, California, United States, 92037
Actively Recruiting
4
Helen Diller Family Comprehensive Cancer Center - UCSF
San Francisco, California, United States, 94115
Actively Recruiting
5
Rocky Mountain Cancer Centres
Denver, Colorado, United States, 80218
Active, Not Recruiting
6
Yale Cancer Center
New Haven, Connecticut, United States, 06510
Actively Recruiting
7
Florida Cancer Specialists
Orlando, Florida, United States, 32806
Actively Recruiting
8
University of Chicago
Chicago, Illinois, United States, 60637
Actively Recruiting
9
Hope and Healing Cancer Center
Hinsdale, Illinois, United States, 60521
Active, Not Recruiting
10
Dana-Faber Cancer Institute
Boston, Massachusetts, United States, 02215
Actively Recruiting
11
Nebraska Hematology Oncology
Lincoln, Nebraska, United States, 68506
Active, Not Recruiting
12
Carolina BioOncology Institute
Huntersville, North Carolina, United States, 28078
Active, Not Recruiting
13
Texas Oncology
Tyler, Texas, United States, 75702
Actively Recruiting
14
Virginia Cancer Specialists
Fairfax, Virginia, United States, 22031
Active, Not Recruiting
15
Fred Hutchinson Cancer Center at University of Washington
Seattle, Washington, United States, 98195
Actively Recruiting
16
ICM-Val d'Aurelle
Montpellier, France, 34298
Actively Recruiting
17
CHU de Poitiers
Poitiers, France, 86000
Actively Recruiting
18
Institut de Cancerologie de l'Ouest
Saint-Herblain, France, 44085
Actively Recruiting
19
Gustave Roussy
Villejuif, France, 94805
Actively Recruiting
20
Careggi University Hospital
Florence, Italy, 50314
Actively Recruiting
21
European Institute of Oncology IRCCS
Milan, Italy, 20141
Actively Recruiting
22
Fondazione Policlinico Gemelli, IRCCS
Rome, Italy, 00168
Actively Recruiting
23
Centro Richerche Cliniche di Verona
Verona, Italy, 37134
Actively Recruiting
24
Institute of Oncology/ARENSIA Exploratory Medicine
Chisinau, Moldova, MD-2025
Withdrawn
25
Aresnsia Research Clinic Bucharest
Bucharest, Romania, 22328
Actively Recruiting
26
Aresnsia Research Clinic Cluj-Napoca
Cluj-Napoca, Romania, 400015
Actively Recruiting
27
Centrul de Oncologie Sf. Nectarie
Iași, Romania, 200347
Actively Recruiting
28
Centrul de Oncologie Euroclinic
Iași, Romania, 700106
Actively Recruiting
29
Barcelona IOB Hospital Quironsalud (NEXT)
Barcelona, Spain, 08023
Actively Recruiting
30
Vall d-Hebron Institut d'Oncologia
Barcelona, Spain, 08035
Actively Recruiting
31
Fundacion Jimenez Diaz (START)
Madrid, Spain, 28040
Actively Recruiting
32
Hospital Clinico Universitario de Valencia
Valencia, Spain, 46010
Actively Recruiting
33
University of Birmingham NHS Foundation Trust
Birmingham, United Kingdom, B15 2TH
Actively Recruiting
34
University of Cambridge NHS Foundation Trust
Cambridge, United Kingdom, CB2 0QQ
Actively Recruiting
35
Velindre Cancer Centre
Cardiff, United Kingdom, CF15 7QZ
Actively Recruiting
36
Leeds University Hospitals NHS Trust
Leeds, United Kingdom, LS9 7LP
Actively Recruiting
37
Guy's and St Thomas' Clinical Research Facility
London, United Kingdom, SE1 9RT
Actively Recruiting
38
Imperial Experimental Cancer Medicine Centre
London, United Kingdom, W12 0NN
Actively Recruiting
39
The Christie Hospital
Manchester, United Kingdom, M20 4BX
Actively Recruiting
40
University of Liverpool - Clatterbridge Medical Centre
Metropolitan Borough of Wirral, United Kingdom, CH63 4JY
Actively Recruiting
41
University of Southampton
Southampton, United Kingdom, SO16 6YD
Actively Recruiting
Research Team
I
Ian Hodgson, PhD
CONTACT
R
Rodney Carter, BSc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
15
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