Actively Recruiting
Phase 2/3 Study of KPL-387 in Recurrent Pericarditis
Led by Kiniksa Pharmaceuticals International, plc · Updated on 2026-05-04
165
Participants Needed
52
Research Sites
231 weeks
Total Duration
On this page
Sponsors
K
Kiniksa Pharmaceuticals International, plc
Lead Sponsor
K
Kiniksa Pharmaceuticals, GmbH
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study is being done to demonstrate whether KPL-387 is an effective and safe treatment for recurrent pericarditis.
CONDITIONS
Official Title
Phase 2/3 Study of KPL-387 in Recurrent Pericarditis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of recurrent pericarditis
- Signs and symptoms of recurrent pericarditis despite standard therapies
- Weighs at least 40 kg
- Phase 2: Taking NSAIDs and/or colchicine in any combination
- Phase 3: Taking NSAIDs and/or colchicine and/or glucocorticoids in any combination
You will not qualify if you...
- Pericarditis secondary to specific prohibited causes
- Received or planning to receive an investigational drug within 4 weeks before or during the study
- History of active or untreated, latent tuberculosis prior to screening
- History of immunodeficiency
- History of immunosuppression including positive HIV test
- Chest x-ray showing malignancy or infection consistent with TB or active infection within 12 weeks before first study drug
- History of malignancy within past 5 years except certain treated skin or cervical cancers
- Known or suspected current active infection or history of chronic/recurrent infections (>3 episodes in prior 12 months)
- Serious infection requiring hospitalization or antibiotics within 2 weeks prior to first study drug
- History of organ transplant except corneal transplant over 3 months before first study drug
- Any other medical condition that could affect participation or study evaluations as judged by the investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 52 locations
1
Investigational Site 018
Gilbert, Arizona, United States, 85297
Actively Recruiting
2
Investigational Site 030
Los Angeles, California, United States, 90048
Actively Recruiting
3
Investigational Site 008
San Francisco, California, United States, 94158
Actively Recruiting
4
Investigational Site 044
Santa Monica, California, United States, 90404
Actively Recruiting
5
Investigational Site 016
Westminster, Colorado, United States, 80023
Actively Recruiting
6
Investigational Site 001
Columbus, Georgia, United States, 31904
Withdrawn
7
Investigational Site 004
Chicago, Illinois, United States, 60611
Actively Recruiting
8
Investigational Site 014
Indianapolis, Indiana, United States, 46184
Actively Recruiting
9
Investigational Site 002
Overland Park, Kansas, United States, 66221
Withdrawn
10
Investigational Site 043
Baltimore, Maryland, United States, 21287
Actively Recruiting
11
Investigational Site 012
Rochester, Minnesota, United States, 55905
Actively Recruiting
12
Investigational Site 050
Kansas City, Missouri, United States, 64111
Actively Recruiting
13
Investigational Site 046
Kansas City, Missouri, United States, 66160
Actively Recruiting
14
Investigational Site 015
New York, New York, United States, 10016
Actively Recruiting
15
Investigational Site 022
New York, New York, United States, 10032
Actively Recruiting
16
Investigational Site 009
Cincinnati, Ohio, United States, 45219
Actively Recruiting
17
Investigational Site 003
Cleveland, Ohio, United States, 44195
Actively Recruiting
18
Investigational Site 005
Austin, Texas, United States, 78705
Actively Recruiting
19
Investigational Site 013
Houston, Texas, United States, 77030
Actively Recruiting
20
Investigational Site 042
Burlington, Vermont, United States, 05401
Actively Recruiting
21
Investigational Site 006
Charlottesville, Virginia, United States, 22903
Actively Recruiting
22
Investigational Site 023
Norfolk, Virginia, United States, 23507
Actively Recruiting
23
Investigational Site 045
Richmond, Virginia, United States, 23284
Actively Recruiting
24
Investigational Site 027
Ottawa, Ontario, Canada, K1N 6N5
Actively Recruiting
25
Investigational Site 028
Montpellier, France, 34090
Actively Recruiting
26
Investigational Site 021
Paris, France, 75013
Actively Recruiting
27
Investigational Site 036
Pessac, France, 33600
Actively Recruiting
28
Investigational Site 019
Poitiers, France, 86000
Actively Recruiting
29
Investigational Site 037
Toulouse, France, 31400
Actively Recruiting
30
Investigational Site 038
Toulouse, France, 31400
Actively Recruiting
31
Investigational Site 052
Dresden, Germany, 01069
Actively Recruiting
32
Investigational Site 034
Athens, Greece, 115 28
Actively Recruiting
33
Investigational Site 039
Nea Ionia, Greece, 142 33
Actively Recruiting
34
Investigational Site 032
Voula, Greece, 166 73
Actively Recruiting
35
Investigational Site 029
Genoa, Italy, 16132
Actively Recruiting
36
Investigational Site 040
Genoa, Italy, 16147
Actively Recruiting
37
Investigational Site 007
Milan, Italy, 20157
Actively Recruiting
38
Investigational Site 051
Padua, Italy, 35143
Actively Recruiting
39
Investigational Site 033
Udine, Italy, 33100
Actively Recruiting
40
Investigational Site 041
Varese, Italy, 21100
Actively Recruiting
41
Investigational Site 051
Warsaw, Poland, 02-097
Actively Recruiting
42
Investigational Site 031
Warsaw, Poland, 02-507
Actively Recruiting
43
Investigational Site 025
Belgrade, Serbia, 11000
Actively Recruiting
44
Investigational Site 026
Belgrade, Serbia, 11040
Actively Recruiting
45
Investigational Site 048
Barcelona, Spain, 08017
Actively Recruiting
46
Investigational Site 010
Barcelona, Spain, 8035
Actively Recruiting
47
Investigational Site 024
Madrid, Spain, 28850
Actively Recruiting
48
Investigational Site 011
Murcia, Spain, 30120
Actively Recruiting
49
Investigational Site 020
London, United Kingdom, EC1A 7BE
Actively Recruiting
50
Investigational Site 047
London, United Kingdom, NW3 2QG
Actively Recruiting
51
Investigational Site 035
London, United Kingdom, SE1 7EH
Actively Recruiting
52
Investigational Site 017
Southampton, United Kingdom, SO17 1BJ
Actively Recruiting
Research Team
C
Clinical Project Manager
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
7
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here