Actively Recruiting
Phase 1 Study of MRTX1719 in Solid Tumors With MTAP Deletion
Led by Bristol-Myers Squibb · Updated on 2025-12-05
336
Participants Needed
25
Research Sites
287 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a Phase 1, open-label, multicenter, study of the safety, tolerability, PK, PD, and anti-tumor activity of MRTX1719 patients with advanced, unresectable or metastatic solid tumor malignancy with homozygous deletion of the MTAP gene.
CONDITIONS
Official Title
Phase 1 Study of MRTX1719 in Solid Tumors With MTAP Deletion
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histologically confirmed solid tumor with homozygous deletion of the MTAP gene detected in tumor tissue
- Unresectable or metastatic disease
- Tumor lesion suitable for mandatory biopsy at baseline and during study unless unsafe or infeasible
- Age 18 years or older
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
- Adequate organ function
You will not qualify if you...
- Prior treatment with PRMT5 or MAT2A inhibitor therapy
- Active brain metastases or carcinomatous meningitis
- Significant hemoptysis or hemorrhage within 4 weeks before first study treatment dose
- Major surgery within 4 weeks before first study treatment dose
- History of intestinal disease, inflammatory bowel disease, major gastric surgery, or gastrointestinal conditions likely to affect drug absorption or swallowing
- Cardiac abnormalities
- Other protocol-defined inclusion/exclusion criteria apply
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 25 locations
1
Mayo Clinic
Phoenix, Arizona, United States, 85054-4502
Actively Recruiting
2
Sarah Cannon Research Institute (SCRI) - HealthONE Location
Denver, Colorado, United States, 80218-1238
Actively Recruiting
3
Rocky Mountain Cancer Centers, LLP - Oncology
Lone Tree, Colorado, United States, 80124
Actively Recruiting
4
Mayo Clinic
Jacksonville, Florida, United States, 32224
Actively Recruiting
5
Sarah Cannon Research Institute at Florida Cancer Specialists
Orlando, Florida, United States, 32827
Actively Recruiting
6
Local Institution - 124
Chicago, Illinois, United States, 60637
Withdrawn
7
Dana-Farber Cancer Institute
Brookline, Massachusetts, United States, 02251
Actively Recruiting
8
Cancer and Hematology Centers of Western Michigan
Norton Shores, Michigan, United States, 49444
Actively Recruiting
9
Mayo Clinic
Rochester, Minnesota, United States, 55905
Actively Recruiting
10
Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey, United States, 08901
Actively Recruiting
11
Local Institution - 129
Mineola, New York, United States, 11501
Not Yet Recruiting
12
David H Koch, Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10021
Actively Recruiting
13
New york cancer and blood specialists - Oncology
Port Jefferson Station, New York, United States, 11776
Actively Recruiting
14
New york cancer and blood specialists - Oncology
Port Jefferson Station, New York, United States, 11776
Actively Recruiting
15
University of North Carolina - Gastroenterology and Hepatology
Chapel Hill, North Carolina, United States, 27599
Actively Recruiting
16
University of North Carolina
Chapel Hill, North Carolina, United States, 27599
Actively Recruiting
17
Vanderbilt - Ingram Cancer Center
Nashville, Tennessee, United States, 37232-5505
Actively Recruiting
18
Ut Southwestern
Dallas, Texas, United States, 75235
Actively Recruiting
19
Texas Oncology - DFW
Fort Worth, Texas, United States, 76104
Actively Recruiting
20
MDACC
Houston, Texas, United States, 77030
Actively Recruiting
21
South Texas Accelerated Research Therapeutics
San Antonio, Texas, United States, 78229
Actively Recruiting
22
Texas Oncology, P.A. - Oncology
Tyler, Texas, United States, 78503
Actively Recruiting
23
Virginia Cancer Specialists, PC
Fairfax, Virginia, United States, 22031
Actively Recruiting
24
Local Institution - 134
Seattle, Washington, United States, 98109
Withdrawn
25
Local Institution - 108
Milwaukee, Wisconsin, United States, 53226
Completed
Research Team
B
BMS Clinical Trials Contact Center www.BMSClinicalTrials.com
CONTACT
F
First line of the email MUST contain the NCT# and Site #.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
3
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