Actively Recruiting
A Phase 1 Study of NRM-823 in Participants With Locally Advanced or Metastatic Refractory Solid Tumors
Led by Normunity AccelCo, Inc. · Updated on 2026-02-12
150
Participants Needed
9
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is being done to find out of NRM-823 is safe and can treat participants with locally advanced or metastatic solid tumors.
CONDITIONS
Official Title
A Phase 1 Study of NRM-823 in Participants With Locally Advanced or Metastatic Refractory Solid Tumors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Have histologically- or cytologically-confirmed advanced or metastatic NSCLC (squamous or adenocarcinoma), TNBC, HNSCC, ESCC, esophageal adenocarcinoma, gastric/GEJ adenocarcinoma, cervical, endometrial, or ovarian cancer
- Have an Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1
- Have adequate liver, kidney, lung, and heart function
- Have adequate blood (hematologic) function
You will not qualify if you...
- Received cytotoxic chemotherapy, biologic anticancer agents, checkpoint inhibitors, or radiation therapy (except bone-only radiation) within 3 weeks or 5 half-lives before the first dose of NRM-823
- History of Grade 2 or higher pneumonitis requiring steroids or any Grade 3 or 4 pneumonitis from prior therapy
- Received investigational therapy less than 4 weeks or 5 half-lives before starting NRM-823
- Have unresolved toxicities from prior therapy above Grade 1, except alopecia and Grade 2 or lower neuropathy
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 9 locations
1
Normunity Investigational Site
Denver, Colorado, United States, 80220
Actively Recruiting
2
Normunity Investigational Site
New Haven, Connecticut, United States, 06519
Actively Recruiting
3
Normunity Investigational Site
Minneapolis, Minnesota, United States, 55425
Actively Recruiting
4
Normunity Investigational Site
Maumee, Ohio, United States, 43537
Actively Recruiting
5
Normunity Investigational Site
Philadelphia, Pennsylvania, United States, 19107
Actively Recruiting
6
Normunity Investigational Site
Nashville, Tennessee, United States, 37203
Actively Recruiting
7
Normunity Investigational Site
Dallas, Texas, United States, 75230
Actively Recruiting
8
Normunity Investigational Site
San Antonio, Texas, United States, 78229
Actively Recruiting
9
Normunity Investigational Site
Fairfax, Virginia, United States, 22031
Actively Recruiting
Research Team
J
Judy Schnyder, MBA
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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