Actively Recruiting
A Phase 1 Study of WVE-007 in Adults Living With Overweight or Obesity
Led by Wave Life Sciences Ltd. · Updated on 2026-02-10
136
Participants Needed
6
Research Sites
86 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of WVE-007 when administered subcutaneously (SC) as single ascending doses in adults who are affected by overweight or obesity.
CONDITIONS
Official Title
A Phase 1 Study of WVE-007 in Adults Living With Overweight or Obesity
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male and female participants aged 18 to 60 years
- BMI 28 to 35 kg/m2 stable within ±5% for the previous 3 to 6 months
- Healthy based on medical history, physical exam, and laboratory tests as judged by the Investigator
You will not qualify if you...
- History or presence of cardiovascular disease including severe heart failure, myocardial infarction, angina, or significant abnormal lab tests
- History or presence of thyroid disorders
- Medical history or diagnosis of liver disease causes
- Use of any siRNA agent in the previous 12 months
- Receipt of any investigational drug within 90 days or 5 half-lives before the first dose or currently in follow-up for another clinical study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 6 locations
1
Parexel International-EPCU Baltimore
Baltimore, Maryland, United States, 21225
Actively Recruiting
2
ARENSIA Research Clinic
Chisinau, Moldova, MD-2025
Actively Recruiting
3
Arensia Clinics S.R.L.
Bucharest, Romania, 011658
Actively Recruiting
4
Spitalul Clinic Judetean De Urgenta Cluj
Cluj-Napoca, Romania, 400006
Actively Recruiting
5
Parexel International Early Phase Clinical Unit
Harrow, United Kingdom, HA1 3UJ
Actively Recruiting
6
Simbec-Orion Clinical Pharmacology
Merthyr Tydfil, United Kingdom, CF48 4DR
Actively Recruiting
Research Team
C
Clinical Operations
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
5
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