Actively Recruiting
A Phase 2 Study of YA-101 in Patients With Multiple System Atrophy
Led by Dasher Neuroscience Inc. · Updated on 2026-04-29
75
Participants Needed
9
Research Sites
95 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a Phase 2, double-blind, placebo-controlled, multi-center, Phase II, dose escalation study to evaluate the safety, tolerability, pharmacokinetics and efficacy of Ya-101 in subjects with multiple system atrophy.
CONDITIONS
Official Title
A Phase 2 Study of YA-101 in Patients With Multiple System Atrophy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Able to understand the process of the clinical trial and give informed consent for the participation of the study.
- Diagnosis of MSA according to MDS clinical criteria (Wenning et al, 2022), including subjects with MSA of either subtype (MSA-P or MSA-C).
- Males or non-pregnant, non-lactating females with no child-bearing potential, or agree to use 2 forms of contraception.
- Able to take oral medications.
- Able to ambulate without the assistance of another person.
You will not qualify if you...
- Positive urine test for drugs of abuse and/or alcohol test both at screening and Day 1.
- Evidence of renal impairment or hepatic impairment.
- Subject with a Mini-Mental State Examination (MMSE) score of 24 or lower.
- Medical history includes severe systemic diseases such as cardiopulmonary failure, severe liver or kidney disease, and uncontrolled diabetes; significant central nervous system disorders like stroke, encephalitis, and epilepsy and severe head trauma; peptic ulcer in one year prior to screening.
- Positive results for active viral infections, including human immunodeficiency virus (HIV), hepatitis B, and hepatitis C.
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 9 locations
1
UCLA Health
Los Angeles, California, United States, 90095
Actively Recruiting
2
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115
Actively Recruiting
3
Mayo Clinic
Rochester, Minnesota, United States, 55905
Actively Recruiting
4
Columbia University Irving medical center
New York, New York, United States, 10032
Actively Recruiting
5
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37232
Actively Recruiting
6
Baylor College of Medicine
Houston, Texas, United States, 77030
Actively Recruiting
7
Juntendo University Hospital
Tokyo, Japan
Actively Recruiting
8
National Taiwan University Hospital
Taipei, Taiwan, 100225
Actively Recruiting
9
National Taiwan University Hospital Cancer Center
Taipei, Taiwan, 106
Not Yet Recruiting
Research Team
E
Email contact via Dasher Neuroscience Inc.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
2
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