Actively Recruiting
A Phase I Trial of 61Cu-NODAGA-PSMA for Patients with Prostate Cancer
Led by Hoag Memorial Hospital Presbyterian · Updated on 2024-12-16
8
Participants Needed
1
Research Sites
24 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Molecular Imaging (MI) uses tracers which emit radiation to provide clinically valuable imaging for patient with cancer. Most current MI agents utilize Fluorine 18 or Gallium 68 as the positron emitter for PET imaging. However, these isotopes have short half-lives which limit the geographic distribution range of tracers made with these isotopes. Copper 61 (61Cu) has a 3.3 hour half-life, which would allow for far greater distribution range following radiotracer production. This phase I trial will test the safety and effectiveness of a novel MI radiotracer that uses 61Cu as its positron emitting isotope and targets Prostate Specific Membrane Antigen (PSMA) for imaging prostate cancer. A successful trial will provide the ability to advance this novel 61Cu-NODAGA-PSMA radioisotope into phase II trials, as well as open a new paradigm into the production of MI radioisotopes with 61Cu.
CONDITIONS
Official Title
A Phase I Trial of 61Cu-NODAGA-PSMA for Patients with Prostate Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Biopsy proven prostate adenocarcinoma
- Age 18 years or older
- ECOG performance status of 0 or 1
- At least one PSMA-positive disease site on PSMA-targeted PET/CT within 30 days prior to enrollment
- Creatinine level of 1.4 or less or creatinine clearance of 60 mL/min or higher
You will not qualify if you...
- Known allergy or hypersensitivity to PSMA-targeted imaging agents
- Presence of another active cancer besides known prostate cancer
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Hoag Memorial Hospital Presbyterian
Irvine, California, United States, 92616
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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