Actively Recruiting
Phase 2 Trial of Adaptive Radiotherapy Boost for HNSCC
Led by H. Lee Moffitt Cancer Center and Research Institute · Updated on 2026-04-01
35
Participants Needed
1
Research Sites
176 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of the study is to determine if it is feasible to use magnetic resonance imaging (MRI) to adjust a portion of radiation therapy for patients with head and neck squamous cell carcinoma . The technique under study will be used to personalize the study treatment based on response, keeping all treatments within standard of care guidelines.
CONDITIONS
Official Title
Phase 2 Trial of Adaptive Radiotherapy Boost for HNSCC
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed and dated informed consent form provided
- Willingness to comply with all study procedures and availability for the study duration
- ECOG performance status of 0 or 1
- Histologically or cytologically confirmed squamous cell carcinoma of oral cavity, oropharynx, nasopharynx, hypopharynx, larynx, or unknown primary in the neck
- Measurable disease at primary site or neck per RECIST 1.1
- Adequate hematologic, hepatic, and renal function if planned to receive chemotherapy
- INR and prothrombin time within normal limits within 28 days before randomization; stable anticoagulation allowed
- Negative serum pregnancy test before starting study treatment in women of childbearing potential
You will not qualify if you...
- Pregnancy or lactation
- Prior radiotherapy to the head and neck or prior systemic therapy for the index cancer
- Prior definitive surgery for the index cancer
- Presence of distant metastatic disease
- Uncontrolled intercurrent illness including ongoing infection or psychiatric/social conditions limiting compliance
AI-Screening
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Trial Site Locations
Total: 1 location
1
Moffitt Cancer Center
Tampa, Florida, United States, 33612
Actively Recruiting
Research Team
A
Ashley Brennaman
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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