Actively Recruiting
A Phase 2 Trial of ALN-APP in Patients With Cerebral Amyloid Angiopathy
Led by Alnylam Pharmaceuticals · Updated on 2026-05-14
200
Participants Needed
57
Research Sites
291 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of the study is to evaluate the effect of ALN-APP on measures of CAA disease progression and to characterize the safety, tolerability, and pharmacodynamics (PD) of ALN-APP in adult patients with sporadic CAA (sCAA) and Dutch-type CAA (D-CAA). The study will be conducted over 2 periods: a 24-month double-blind treatment period and an optional 18-month open-label extension (OLE) period. The estimated duration of study participation, inclusive of screening, treatment, and additional safety follow-up, is up to 50 months.
CONDITIONS
Official Title
A Phase 2 Trial of ALN-APP in Patients With Cerebral Amyloid Angiopathy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- For sporadic CAA patients: 50 years or older
- For sporadic CAA patients: Probable CAA diagnosis per Boston Criteria Version 2.0
- For Dutch-type CAA patients: 30 years or older
- For Dutch-type CAA patients: Known E693Q amyloid precursor protein (APP) gene mutation
You will not qualify if you...
- Moderate or severe Alzheimer's disease or significant cognitive impairment
- Clinical intracerebral hemorrhage within 90 days prior to randomization
- Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) greater than 3 times upper limit of normal at screening
- Estimated glomerular filtration rate (eGFR) less than 30 mL/min/1.73m² at screening
- Recent receipt of an investigational agent
- Prior treatment with amyloid-targeting antibody
- Other protocol defined exclusion criteria apply
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 57 locations
1
Clinical Trial Site
Los Angeles, California, United States, 90095
Active, Not Recruiting
2
Clinical Trial Site
Orange, California, United States, 92868
Active, Not Recruiting
3
Clinical Trial Site
Palo Alto, California, United States, 94304
Active, Not Recruiting
4
Clinical Trial Site
Sacramento, California, United States, 95816
Active, Not Recruiting
5
Clinical Trial Site
San Francisco, California, United States, 94114
Active, Not Recruiting
6
Clinical Trial Site
Aurora, Colorado, United States, 80045
Active, Not Recruiting
7
Clinical Trial Site
New Haven, Connecticut, United States, 06510
Active, Not Recruiting
8
Clinical Trial Site
Gainesville, Florida, United States, 32608
Active, Not Recruiting
9
Clinical Trial Site
Jacksonville, Florida, United States, 32224
Active, Not Recruiting
10
Clinical Trial Site
Maitland, Florida, United States, 32751
Active, Not Recruiting
11
Clinical Trial Site
Naples, Florida, United States, 34105
Active, Not Recruiting
12
Clinical Trial Site
Chicago, Illinois, United States, 60612
Active, Not Recruiting
13
Clinical Trial Site
Lexington, Kentucky, United States, 40504
Active, Not Recruiting
14
Clinical Trial Site
New Orleans, Louisiana, United States, 70121
Active, Not Recruiting
15
Clinical Trial Site
Boston, Massachusetts, United States, 02114
Active, Not Recruiting
16
Clinical Trial Site
Plymouth, Massachusetts, United States, 02360
Active, Not Recruiting
17
Clinical Trial Site
Rochester, Minnesota, United States, 55905
Active, Not Recruiting
18
Clinical Trial Site
St Louis, Missouri, United States, 63110
Active, Not Recruiting
19
Clinical Trial Site
Hackensack, New Jersey, United States, 07601
Active, Not Recruiting
20
Clinical Trial Site
New York, New York, United States, 10016
Active, Not Recruiting
21
Clinical Trial Site
New York, New York, United States, 10029
Active, Not Recruiting
22
Clinical Trial Site
New York, New York, United States, 10032
Active, Not Recruiting
23
Clinical Trial Site
New York, New York, United States, 10065
Active, Not Recruiting
24
Clinical Trial Site
Durham, North Carolina, United States, 27705
Active, Not Recruiting
25
Clinical Trial Site
Canton, Ohio, United States, 44718
Active, Not Recruiting
26
Clinical Trial Site
Cleveland, Ohio, United States, 44195
Active, Not Recruiting
27
Clinical Trial Site
Abington, Pennsylvania, United States, 19001
Active, Not Recruiting
28
Clinical Trial Site
Philadelphia, Pennsylvania, United States, 19104
Active, Not Recruiting
29
Clinical Trial Site
Pittsburgh, Pennsylvania, United States, 15213
Active, Not Recruiting
30
Clinical Trial Site
Dallas, Texas, United States, 75243
Active, Not Recruiting
31
Clinical Trial Site
Dallas, Texas, United States, 75390
Active, Not Recruiting
32
Clinical Trial Site
Houston, Texas, United States, 77030
Active, Not Recruiting
33
Clinical Trial Site
San Antonio, Texas, United States, 78229
Active, Not Recruiting
34
Clinical Trial Site
Seattle, Washington, United States, 98104
Active, Not Recruiting
35
Clinical Trial Site
Adelaide, Australia, 5000
Actively Recruiting
36
Clinical Trial Site
Brisbane, Australia, 4029
Actively Recruiting
37
Clinical Trial Site
Heidelberg, Australia, 3084
Actively Recruiting
38
Clinical Trial Site
Nedlands, Australia, 6009
Actively Recruiting
39
Clinical Trial Site
Parkville, Australia, 3050
Actively Recruiting
40
Clinical Trial Site
Calgary, Canada, T2N 4Z6
Actively Recruiting
41
Clinical Trial Site
Hamilton, Canada, L8L 2X2
Actively Recruiting
42
Clinical Trial Site
Kelowna, Canada, V1Y 1Z9
Actively Recruiting
43
Clinical Trial Site
Moncton, Canada, E1C 2Z3
Actively Recruiting
44
Clinical Trial Site
Montreal, Canada, H3A 2B4
Actively Recruiting
45
Clinical Trial Site
Montreal, Canada, H3G 1H9
Actively Recruiting
46
Clinical Trial Site
Ottawa, Canada, K1Z 1G3
Actively Recruiting
47
Clinical Trial Site
Toronto, Canada, M3B 2S7
Actively Recruiting
48
Clinical Trial Site
Victoria, Canada, V8R 1J8
Actively Recruiting
49
Clinical Trial Site
Amsterdam, Netherlands, 1081 GN
Actively Recruiting
50
Clinical Trial Site
Leiden, Netherlands, 2333ZA
Actively Recruiting
51
Clinical Trial Site
Nijmegen, Netherlands, 6525 GA
Actively Recruiting
52
Clinical Trial Site
Bern, Switzerland, 3010
Actively Recruiting
53
Clinical Trial Site
Geneva, Switzerland, 1205
Actively Recruiting
54
Clinical Trial Site
Sankt Gallen, Switzerland, 9007
Terminated
55
Clinical Trial Site
Glasgow, United Kingdom, G51 4TF
Actively Recruiting
56
Clinical Trial Site
London, United Kingdom, SE5 8AF
Active, Not Recruiting
57
Clinical Trial Site
London, United Kingdom, WC1N 3BG
Active, Not Recruiting
Research Team
A
Alnylam Clinical Trial Information Line
CONTACT
A
Alnylam Clinical Trial Information Line
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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