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A Phase 2, Randomized, Double-blind, Placebo-controlled Trial to Investigate the Efficacy and Safety of 2 Doses of Vipoglanstat in Patients With Moderate to Severe Endometriosis-related Pain - the NOVA Trial
Led by Gesynta Pharma AB · Updated on 2026-04-17
190
Participants Needed
41
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the effects of vipoglanstat on non-menstrual pelvic pain (NMPP) related to endometriosis in women aged 18 to 44 years. This Phase 2 trial aims to assess how well vipoglanstat works and its safety in treating moderate to severe pain caused by endometriosis. The study is sponsored by Gesynta Pharma AB and is designed as a randomized, double-blind, placebo-controlled trial.
CONDITIONS
Brief Title
A Phase 2 Trial to Investigate Efficacy and Safety of Vipoglanstat in Women With Endometriosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Premenopausal females 18 to under 45 years old at Visit 1
- Confirmed diagnosis of endometriosis within the last 10 years by surgery or imaging
- History of non-menstrual pelvic pain significantly affecting daily life
- Reports moderate to very severe pain during non-menstrual days in the month before Visit 2
You will not qualify if you...
- Chronic pelvic pain not primarily caused by endometriosis (such as chronic infection, interstitial cystitis, nerve problems, non-endometriosis pelvic adhesions, persistent ovarian cysts, posttubal ligation, hydrosalpinx, or vaginismus)
- More than two prior surgical procedures for endometriosis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Approximately 4 menstrual cycles
Participants receive vipoglanstat or placebo capsules orally for approximately 4 menstrual cycles to assess efficacy and safety for endometriosis-related pain.
Visits may occur monthly during treatment
Trial Site Locations
Total: 41 locations
1
MHAT Puls AD
Blagoevgrad, Bulgaria, 2700
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2
Lyulin Hospital
Sofia, Bulgaria, 1336
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3
FemiClinic
Sofia, Bulgaria, 1700
Actively Recruiting
4
Gynekologie MEDA s.r.o
Brno, Czechia, 60200
Actively Recruiting
5
Fakultni nemocnice Brno
Brno, Czechia, 62500
Actively Recruiting
6
NEUMED Gynekologicka Ambulance s.r.o.
Olomouc, Czechia, 77900
Actively Recruiting
7
Gyncare MUDr. Michael Svec s.r.o.
Pilsen, Czechia, 32600
Actively Recruiting
8
STELLA-GYN, s.r.o.
Vodňany, Czechia, 38901
Actively Recruiting
9
MedEnd
Budapest, Hungary, 1027
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10
Semmelweis Egyetem II. Sz. Szuleszeti es Nogyogyaszati Klinika
Budapest, Hungary, 1082
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11
Robert Karoly Private Hospital Tritonlife Medical Center
Budapest, Hungary, 1134
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12
Debreceni Egyetem Klinikai Kozpont
Debrecen, Hungary, 4032
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13
Somogy Varmegyei Kaposi Mor Oktato Korhaz (Kaposi Mor County Hospital)
Kaposvár, Hungary, 7400
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14
A.O. San Martino Genova Universita di Genova
Genova, Italy, 16132
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15
Prywatna Klinika Polozniczo - Ginekologiczna Sp. Z O.O.
Bialystok, Poland, 15-224
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16
Centrum Ginekologii Artemida
Bialystok, Poland, 15-464
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17
In- Vivo Sp. z o. o.
Bydgoszcz, Poland, 85-048
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18
NZOZ Medem
Katowice, Poland, 40-301
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19
Centrum Medyczne Angelius Provita
Katowice, Poland, 40-611
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20
NZOZ Vita Longa Sp. z o.o.
Katowice, Poland, 40-748
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21
Medico Praktyka Lekarska
Krakow, Poland, 31315
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22
Centrum Medyczne Chodzki
Lublin, Poland, 20-093
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23
ETG Siedlce
Siedlce, Poland, 08-110
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24
Aidport sp. Z o.o.
Skorzewo, Poland, 60-185
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25
Twoja Przychodnia SCM
Szczecin, Poland, 71-500
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26
Specjalistyczna Praktyka Lekarska Krzysztof Dynowski
Warsaw, Poland, 00-144
Actively Recruiting
27
ETG JustMed
Warsaw, Poland, 01-691
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28
Genesys Fertility Center
Bucharest, Romania, 012071
Actively Recruiting
29
Delta Health Care
Bucharest, Romania, 014142
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30
SC Centrul Medical Unirea SRL - Regina Maria
Iași, Romania, 700023
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31
SC Centrul Medical Unirea SRL
Târgu Mureş, Romania, 540139
Actively Recruiting
32
Accellacare Yorkshire
Bradford, United Kingdom, BD18 3SA
Actively Recruiting
33
Southmead Hospital - North Bristol NHS Trust
Bristol, United Kingdom, BS10 5NB
Actively Recruiting
34
Accellacare Northamptonshire
Corby, United Kingdom, NN18 9EZ
Actively Recruiting
35
Accellacare Warwickshire
Coventry, United Kingdom, CV3 4FJ
Actively Recruiting
36
Guy's and St Thomas' NHS Foundation Trust
London, United Kingdom, SE1 7EH
Actively Recruiting
37
Accellacare North London
Northwood, United Kingdom, HA6 2RN
Actively Recruiting
38
Norfolk and Norwich University Hospital - Norfolk and Norwich University Hospitals NHS Foundation Trust
Norwich, United Kingdom, NR4 7UY
Actively Recruiting
39
Accellacare South London
Orpington, United Kingdom, BR5 3QG
Actively Recruiting
40
University of Oxford
Oxford, United Kingdom, OX3 9DU
Actively Recruiting
41
Southampton General Hospital - University Hospital Southampton NHS Foundation Trust
Southampton, United Kingdom, SO16 6YD
Actively Recruiting
Research Team
C
CMO VP Clinical Development
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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