Actively Recruiting
Phenotype/Genotype Correlations in Movement Disorders
Led by National Institute of Neurological Disorders and Stroke (NINDS) · Updated on 2026-05-04
2500
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this protocol is to identify families with inherited movement disorders and evaluate disease manifestations to establish an accurate clinical diagnosis by using newest technological advances and investigate the underlying molecular mechanisms. Studies of inherited movement disorders in large families with good genealogical records are especially valuable. Patients with diseases of known molecular basis will be genotyped in order to investigate phenotype/genotype correlation. Patients with disease of unknown or incomplete genetic characterization will be studied with a hope of contributing to the identification of specific disease-causing genes and genetic mechanisms responsible for a specific disorder.
CONDITIONS
Official Title
Phenotype/Genotype Correlations in Movement Disorders
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Individuals with suspected movement disorders
- Family members of movement disorders patients
- Ability to give informed consent or have a legally authorized representative able to give consent (for adults without consent capacity) or parent/guardian able to provide informed consent (for a child)
- If unable to give informed consent, ability to give assent (for children or adults without consent capacity)
- NIH Employees can participate in this study if they meet eligibility.
You will not qualify if you...
- Pregnant women
- Children less than 2 years of age
- Employees of the Parkinson's Disease Clinic, NINDS
- Presence of metal in body unsafe for MRI, such as pacemakers, stimulators, pumps, aneurysm clips, metallic prostheses, artificial heart valves, cochlear implants, shrapnel fragments, or history of metal work like welding
- Claustrophobia making MRI uncomfortable
- Unable to lie comfortably on back for up to 1 hour
- Children under 12 years of age for MRI eligibility
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
K
Konjit Yirgashewa
CONTACT
D
Debra J Ehrlich, M.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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