Actively Recruiting
Phenotyping Genetic Risk for Type 2 Diabetes
Led by University of Pennsylvania · Updated on 2025-09-10
100
Participants Needed
2
Research Sites
367 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study tests the hypothesis that non-diabetic individuals with a high genetic risk score for type 2 diabetes have impaired glucose tolerance and insulin resistance compared to those with a low genetic risk score for type 2 diabetes.
CONDITIONS
Official Title
Phenotyping Genetic Risk for Type 2 Diabetes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 10 to 70 years
- Prior participant of the UPenn Biobank or Center for Applied Genomics Biobank who agreed to be recontacted for future research
- Adults with a body mass index (BMI) of 25 kg/m2 or higher
- Children and adolescents with BMI at or above the 85th percentile
You will not qualify if you...
- Prior diagnosis of type 1, type 2, or secondary diabetes
- Use of medications that affect glucose and insulin response such as steroids, metformin, or other anti-diabetic drugs
- Acute illness affecting insulin and glucose dynamics
- Pregnancy
- Hypothalamic obesity or related genetic disorder of metabolism
- Recent systemic chemotherapy use
- Gastrointestinal impairment or surgery affecting absorption
- Anemia
- Major organ system illness or any condition requiring regular medication or treatment that could interfere with the study
- Inability to comply with study protocol
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Childrens Hospital of Philadelphia
Philadelphia, Pennsylvania, United States, 19104
Not Yet Recruiting
2
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
Research Team
J
Jessica R Wilson, MD, MS
CONTACT
E
Esther Oyerinde
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
1
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