Actively Recruiting
Phenotyping of Postural Orthostatic Tachycardia Syndrome (POTS)
Led by University of Texas Southwestern Medical Center · Updated on 2025-06-27
350
Participants Needed
1
Research Sites
251 weeks
Total Duration
On this page
Sponsors
U
University of Texas Southwestern Medical Center
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is an observational study to deeply phenotype the disorder of POTS using multiple testing modalities.
CONDITIONS
Official Title
Phenotyping of Postural Orthostatic Tachycardia Syndrome (POTS)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 14 years or older and able to provide informed consent (assent with parental consent if under 18)
- Meets consensus criteria for POTS including sustained heart rate increase with standing, absence of orthostatic hypotension, symptoms improving with sitting or lying down, resting heart rate under 100 bpm, and symptoms present for at least 6 months
- Stable oral medication regimen for at least 14 days
- For control group: healthy women aged 18 to 30 years without POTS or orthostatic intolerance symptoms and resting heart rate under 100 bpm
- Ability to comply with study procedures
You will not qualify if you...
- Use of amphetamine-type stimulants, diuretics, selective norepinephrine reuptake inhibitors, anticholinergic medications (including tricyclic antidepressants), fludrocortisone, or desmopressin within past 14 days
- Use of other autonomic drugs (adrenergic agents, pyridostigmine, droxidopa, triptans, ivabradine) within past 48 hours
- Receiving intravenous immunoglobulin (IVIG), subcutaneous IgG, or any investigational medication within past year
- Infusion of intravenous fluids within past 7 days
- History or evidence of other conditions explaining symptoms or orthostatic tachycardia, such as structural heart disease, cerebrospinal fluid hypovolemia, or severe traumatic brain injury
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
UT Southwestern Medical Center
Dallas, Texas, United States, 75208
Actively Recruiting
Research Team
S
Steve Hopkins
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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