Actively Recruiting
Phenotyping Resting and Exertional Right Ventricular Dysfunction Among Patients With Chronic Obstructive Pulmonary Disease
Led by University of Colorado, Denver · Updated on 2026-05-08
60
Participants Needed
1
Research Sites
13 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying heart function in people with chronic obstructive pulmonary disease (COPD) to better understand how the right side of the heart responds during rest and different levels of exercise. This study focuses on identifying patterns of right ventricular dysfunction, which may help guide improved treatments for COPD patients in the future. Participants will undergo testing while resting and during moderate- and high-intensity exercise. After a brief warmup, they will perform about 5 minutes of moderate exercise followed by roughly 2 minutes of high-intensity exercise. These activities help identify how the right ventricle of the heart responds under different conditions. During the study, heart function will be measured using transthoracic echocardiography and, in some cases, conductance catheter techniques. Researchers will also assess participants' quality of life through questionnaires, measure maximum oxygen consumption, analyze blood samples for specific compounds, and monitor physical activity over a week. Each assessment session lasts up to 1 hour, with physical activity tracked for 7 days. The study is sponsored by the University of Colorado, Denver, and participation involves these tests and monitoring to understand heart response in COPD.
CONDITIONS
Brief Title
Phenotyping Resting and Exertional Right Ventricular Dysfunction Among Patients With Chronic Obstructive Pulmonary Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of COPD confirmed by a forced expiratory volume in 1 second to forced vital capacity ratio less than 0.7
- Age 40 years or older
You will not qualify if you...
- COPD exacerbation within 3 months before enrollment
- Change in COPD therapy within 3 weeks before enrollment
- Need for more than 6 liters per minute supplemental oxygen at rest
- Need for more than 10 liters per minute supplemental oxygen with exertion
- Active or uncontrolled cardiovascular disease such as hypertension with blood pressure above 150/100 despite medication, coronary artery disease with angina, left ventricular ejection fraction 40% or less, arrhythmia, or moderate to severe valvular abnormalities
- Volume overload signs like jugular vein distension or peripheral edema
- World Health Organization Functional Class IV
- Known pulmonary hypertension with mean pulmonary artery pressure over 45 mmHg
- Untreated severe obstructive sleep apnea or obesity hypoventilation syndrome
- Active cancer except skin cancer
- Medical conditions limiting exercise on an upright stationary bicycle (e.g., severe osteoarthritis, balance problems)
- Pregnancy
- Body mass index less than 18 or greater than 40
- Hematocrit less than 25% or greater than 55%
- For invasive CPET, chronic anticoagulation that cannot be stopped for the study
- For invasive CPET, forced expiratory volume in 1 second less than 20%
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 1 hour
Participants perform approximately 5 minutes of moderate-intensity exercise followed by approximately 2 minutes of high-intensity exercise to assess right ventricular responses during exertion.
1 visit (in-person)
Duration - 7 days
Participants wear an activity monitor to measure physical activity over 7 days following exercise testing.
Continuous monitoring over 7 days
Trial Site Locations
Total: 1 location
1
University of Colorado Anschutz Medical Campus
Aurora, Colorado, United States, 80045
Actively Recruiting
Research Team
L
Lindsay Forbes, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
1
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