Actively Recruiting
Phenotyping Resting and Exertional Right Ventricular Dysfunction Among Patients With Chronic Obstructive Pulmonary Disease
Led by University of Colorado, Denver · Updated on 2026-05-08
60
Participants Needed
1
Research Sites
362 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study plans to learn about heart function among individuals with chronic obstructive pulmonary disease (COPD). In particular, the investigators want to understand the different patterns of right ventricular response during rest and moderate- vs high-intensity exercise. By identifying patterns of right ventricular dysfunction, this study will help identify better treatments for patients with COPD in the future.
CONDITIONS
Official Title
Phenotyping Resting and Exertional Right Ventricular Dysfunction Among Patients With Chronic Obstructive Pulmonary Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- COPD confirmed by a ratio of forced expiratory volume in 1 second to forced vital capacity (FEV1/FVC) less than 0.7
- Age 40 years or older
You will not qualify if you...
- COPD exacerbation in the 3 months before enrollment
- Change in COPD treatment in the 3 weeks before enrollment
- Need for more than 6 liters per minute of supplemental oxygen at rest
- Need for more than 10 liters per minute of supplemental oxygen during exercise
- Active or uncontrolled cardiovascular disease including hypertension with blood pressure over 150/100 despite medication, coronary artery disease with angina, left ventricular ejection fraction 40% or less, arrhythmia, or significant valvular abnormalities
- Signs of volume overload such as jugular vein distension or significant peripheral edema
- World Health Organization Functional Class IV
- Known pulmonary hypertension with mean pulmonary artery pressure over 45 mmHg
- Untreated severe obstructive sleep apnea or obesity hypoventilation syndrome
- Active cancer (other than skin cancer)
- Medical conditions limiting exercise on an upright stationary bicycle (e.g., severe osteoarthritis, balance problems)
- Pregnancy
- Body mass index less than 18 or greater than 40
- Hematocrit less than 25% or greater than 55%
- For invasive cardiopulmonary exercise testing (CPET), chronic anticoagulation that cannot be stopped for the study visit
- For invasive CPET, forced expiratory volume in 1 second less than 20%
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Colorado Anschutz Medical Campus
Aurora, Colorado, United States, 80045
Actively Recruiting
Research Team
L
Lindsay Forbes, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here