Actively Recruiting
Phenylalanine-free Diet for Patients With Secondary Hyperphenylalaninemia in ICU
Led by Chang Gung Memorial Hospital · Updated on 2026-03-20
100
Participants Needed
1
Research Sites
282 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Hyperphenylalaninemia is not only present in patients with congenital phenylketonuria. In adults with critical illness, hyperphenylalaninemia is noted in some patients and is associated with high mortality rate. Hyperphenylalaninemia can cause metabolic acidosis, brain dysfunction, and metabolic disturbance. The investigators would like to see whether the phenylalanine-free milk for congenital phenylketonuria is also effective in lowering the blood phenylalanine concentrations in patients with critical illness in intensive care unit and hyperphenylalaninemia.
CONDITIONS
Official Title
Phenylalanine-free Diet for Patients With Secondary Hyperphenylalaninemia in ICU
Who Can Participate
Eligibility Criteria
You may qualify if you...
- APACHE II score of 15 or higher
- Expected ICU stay longer than 48 hours
- Baseline plasma phenylalanine level of 95 m or higher
- Age over 20 years
You will not qualify if you...
- Having other serious illnesses that may limit survival to under three months, such as terminal cancer
- Expected survival less than 3 days
AI-Screening
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Trial Site Locations
Total: 1 location
1
Chang Gung Memorial Hospital
Keelung, Taiwan, 402
Actively Recruiting
Research Team
C
CHAO-HUNG WANG, MD, PhD
CONTACT
M
MIN-HUI LIU, RN, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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