Actively Recruiting
Phenylephrine Tumescence for Hemostasis in Surgery for Burn Injury - A Randomized Control Trial
Led by University of Manitoba · Updated on 2026-05-14
24
Participants Needed
1
Research Sites
30 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the use of phenylephrine compared to epinephrine to control blood loss during skin graft surgery for burn injuries covering 5-30% of total body surface area. This Phase 1 randomized trial aims to find out if phenylephrine can reduce blood loss without affecting heart rate or blood pressure, as epinephrine sometimes causes increases in these vital signs. Participants will receive injections under the skin of the burn injury site with either a phenylephrine solution or the standard epinephrine solution before skin grafting. The procedure and grafting technique remain the same; only the solution used for tumescence differs. The study compares these two drugs to assess their effects during surgery. During the first 30 minutes after injection, researchers will monitor mean arterial blood pressure closely, along with blood pressure and heart rate every 15 minutes. The study involves careful observation of these vital signs to evaluate the safety and effectiveness of phenylephrine in controlling blood loss. The total participation duration and further follow-up details are not specified.
CONDITIONS
Brief Title
Phenylephrine Tumescence for Hemostasis in Surgery for Burn Injury
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Burn injury requiring debridement and grafting between 5-30% total body surface area
- Age between 18 and 75 years
You will not qualify if you...
- Burns on head, neck, hand, foot, or genital areas
- Use of anticoagulants (except NSAIDs)
- Use of monoamine oxidase inhibitors or tricyclic antidepressants
- History of coronary or peripheral vascular disease
- History of arrhythmias
- Use of Beta-blockers
- History of vascular abnormalities
- Hypertension
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - During surgery and immediate post-operative period
Participants receive phenylephrine or epinephrine during surgery for burn injury to control bleeding.
1 surgical visit with monitoring every 15 minutes for 30 minutes
Trial Site Locations
Total: 1 location
1
University of Manitoba
Winnipeg, Manitoba, Canada, R3A 1R9
Actively Recruiting
Research Team
J
Justin Gawaziuk, MSc
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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