Actively Recruiting
Phenylephrine Tumescence for Hemostasis in Surgery for Burn Injury
Led by University of Manitoba · Updated on 2026-05-14
24
Participants Needed
1
Research Sites
734 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The standard of care for treatment of burn injury is to inject a solution of epinephrine under the skin of the injured site in order to reduce blood loss during skin grafting. This solution of epinephrine has been shown to have effects on the body outside the donor site. Some people have increases in heart rate and blood pressure. We will study the effect of a phenylephrine solution in place of an epinephrine solution to control blood loss. We think that phenylephrine will help decrease blood loss and not change blood pressure or heart rate. The injured area will be injected under the skin and a skin graft will be taken in the same way as we usually do. The only change will be the use of phenylephrine in the solution instead of epinephrine. Our goal is to find whether or not phenylephrine or epinephrine solution results in a reduction of blood loss without affecting the rest of the body.
CONDITIONS
Official Title
Phenylephrine Tumescence for Hemostasis in Surgery for Burn Injury
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Burn injury requiring debridement and grafting between 5-30% TBSA
You will not qualify if you...
- Head and neck, hand, foot, or genital burns
- On anticoagulants (except NSAIDs)
- On monoamine oxidase inhibitor or tricyclic antidepressant
- Coronary or peripheral vascular disease
- History of arrhythmias
- On a Beta-blocker
- History of vascular abnormality
- Hypertension
AI-Screening
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Trial Site Locations
Total: 1 location
1
University of Manitoba
Winnipeg, Manitoba, Canada, R3A 1R9
Actively Recruiting
Research Team
J
Justin Gawaziuk, MSc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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