Actively Recruiting
Multistructural Quantitative Photoacoustic Imaging of Human Feet With Lower Extremity Artery Disease
Led by Sun Yat-sen University · Updated on 2026-05-06
200
Participants Needed
1
Research Sites
13 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Lower extremity artery disease (LEAD) is often underdiagnosed and untreated, leading to serious disability and death. Researchers are studying a new imaging method called photoacoustic tomography (PACT) to better evaluate the blood vessels and oxygen levels in the feet of people with LEAD. This technology can create detailed three-dimensional images without using contrast agents, potentially offering more complete information than current tests. Participants in this observational study will include both LEAD patients and healthy volunteers. They will undergo PACT imaging of their feet, which uses special ultrasound and photoacoustic techniques to capture high-resolution images of blood vessels and measure blood oxygen saturation and hemoglobin concentration. The study aims to assess how well this imaging method works and whether it adds value compared to existing diagnostic tools. During the study, participants will have their foot vasculature examined using the PACT system. Researchers will measure vessel density, oxygen saturation, and hemoglobin levels at baseline. The study involves no treatment and focuses on gathering detailed imaging data. Participants will be monitored for safety, and the study will run until the end of 2028, with involvement lasting as needed for imaging and assessments.
CONDITIONS
Brief Title
Photoacoustic Tomography in Assessment of Lower Extremity Artery Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- LEAD patients who voluntarily agree to participate and provide informed consent
- Patients without LEAD confirmed by ultrasound and clinical diagnosis who voluntarily agree to participate and provide informed consent
- Adults aged 18 years or older
You will not qualify if you...
- Age under 18 years
- Pregnant women, nursing mothers, or women preparing for pregnancy
- Individuals with contraindications to laser operation, such as recent photodynamic therapy within the last month
- Presence of metal implants in lower legs or feet
- History of mental illness or abuse of drugs and alcohol
- Blood phobia or pathological hypotension
- History of cerebral hemorrhage, peripheral vascular bleeding risk, or stroke
- Presence of wounds on lower legs or feet
- Inability or unwillingness to cooperate with the study procedures
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Baseline
Participants undergo photoacoustic imaging to assess vessel density, oxygen saturation, and hemoglobin concentration in the foot vasculature.
1 visit (in-person)
Trial Site Locations
Total: 1 location
1
the Third Affiliated Hospital of Sun Yat-sen University
Guangzhou, Guangdong, China, 510630
Actively Recruiting
Research Team
J
Jia Liu, Doctor
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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