Comparing Laser Treatments and Clobetasol for Erosive Oral Lichen Planus A Study on Healing, Pain Relief, and Recurrence Prevention

What this Trial Is About

Researchers are evaluating three treatment methods for the erosive form of oral lichen planus, a chronic inflammatory condition that causes pain, affects oral functions like chewing and swallowing, and often relapses. This trial compares photobiomodulation, Photodynamic Therapy PDT, and topical clobetasol to understand which method best promotes healing, reduces symptoms, and prevents recurrence. The study involves adults diagnosed through biopsy and uses advanced imaging and microbiological tests to confirm disease type before starting treatment. Participants are randomly assigned to one of three groups. The photobiomodulation group receives low-level laser treatment twice weekly for up to eight sessions to stimulate tissue repair. The PDT group uses a photosensitizing gel activated by a laser once weekly for six weeks to target affected tissue. The clobetasol group applies a corticosteroid ointment twice daily for thirty days as standard care. Each treatment follows strict protocols to ensure safety and consistency. During the study, patients will have their lesions measured and scored, pain assessed with validated scales, and photographs taken to track changes. Follow-up visits occur one week, one month, and three months after treatment to monitor healing and relapse. Researchers will also check for infections and side effects throughout. The main outcomes are lesion severity, treatment response, and pain improvement, helping to determine the safest and most effective approach for managing erosive oral lichen planus.

Photobiomodulation, Photodynamic Therapy, and Clobetasol in the Treatment of Oral Lichen Planus.