Actively Recruiting
Photodynamic Therapy for Benign Dermal Neurofibromas- Phase II
Led by Donald Basel · Updated on 2025-05-08
30
Participants Needed
1
Research Sites
487 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The investigators wish to determine the time to disease progression for benign neurofibromas treated with Levulan Kerastick topical photosensitizer and red light photodynamic therapy (PDT) in patients with neurofibromatosis type 1 (NF1). The investigators also wish to measure tumor size for control and treatment tumors in order to gain insights into tumor growth rates.
CONDITIONS
Official Title
Photodynamic Therapy for Benign Dermal Neurofibromas- Phase II
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient is 14 years or older.
- Diagnosed NF1, determined by American Academy of Neurology Guidelines.
- Tumor location on skin of trunk or limbs only.
- Tumor type: superficial dermal neurofibromas 4mm deep or less.
- Patient has provided written informed consent.
- Patient is willing and able to comply with study follow-up requirements.
- Absence of any other malignancy.
You will not qualify if you...
- Life expectancy less than 3 years.
- Pregnancy.
- Cutaneous photosensitivity to wavelengths used in photodynamic therapy.
- Diagnosis of porphyria.
- Allergy to aminolevulinic acid or any topical solution vehicle components.
- Previous chemotherapy within 6 weeks before photodynamic therapy.
- Receiving other concurrent tumor therapy.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Donald G Basel
Milwaukee, Wisconsin, United States, 53226
Actively Recruiting
Research Team
D
Donald G Basel, MD
CONTACT
P
Paula Engelking, BS, CRC
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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