Actively Recruiting
Photon Therapy Versus Proton Therapy in Early Tonsil Cancer.
Led by Lund University Hospital · Updated on 2021-09-01
100
Participants Needed
12
Research Sites
466 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
In this trial, patients with early squamous cell carcinoma of the tonsil with clinical stage T1-2 (p16-positive or p16-negative) N0-1 (p16-positive)/N0-N2b (p16-negative) according to American Joint Committee on Cancer (AJCC) 8th edition, aimed for unimodal and ipsilateral treatment with radiotherapy with curative intent will be included. The patients will be randomized to in a 1:1 ratio to receive radiotherapy with either photons (conventional radiotherapy) versus radiotherapy with protons.
CONDITIONS
Official Title
Photon Therapy Versus Proton Therapy in Early Tonsil Cancer.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient is at least 18 years old
- Histologically or cytologically confirmed, untreated squamous cell carcinoma of the tonsil T1-2 (p16-positive or p16-negative) with specific nodal stages according to AJCC 8th edition
- Treatment planned as unimodal, ipsilateral radiotherapy with curative intent
- Surgery allowed only as salvage treatment after radiotherapy, not before or as part of planned treatment
- WHO/ECOG performance status of 0 or 1
- Ability to understand treatment information and provide written informed consent
You will not qualify if you...
- Patients needing bilateral radiotherapy or combined chemotherapy
- Current or recent malignancies except certain treated skin cancers or cervical carcinoma with sufficient follow-up
- Two or more synchronous primary head and neck cancers at diagnosis
- Previous head and neck surgery or radiotherapy affecting study results
- Co-existing diseases expected to limit survival to less than 2 years
- Psychiatric, addictive, or medical conditions impairing compliance
- Presence of metal dental fillings near tumor area that could affect radiotherapy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 12 locations
1
Gävle Hospital
Gävle, Sweden, SE-803 24
Actively Recruiting
2
Sahlgrenska University Hospital
Gothenburg, Sweden, SE-413 46
Actively Recruiting
3
Jönköping Hospital
Jönköping, Sweden, SE-553 05
Actively Recruiting
4
Karlstad Hospital
Karlstad, Sweden, SE-652 30
Actively Recruiting
5
Linköping University Hospital
Linköping, Sweden, SE-587 50
Actively Recruiting
6
Lund University Hospital
Lund, Sweden, SE-221 85
Actively Recruiting
7
Örebro University Hospital
Örebro, Sweden, SE-703 82
Actively Recruiting
8
Karolinska University Hospital
Stockholm, Sweden, SE-171 64
Actively Recruiting
9
University Hospital
Umeå, Sweden, SE-907 37
Actively Recruiting
10
Scandion clinic
Uppsala, Sweden, SE-752 37
Actively Recruiting
11
Uppsala Accademical Hospital
Uppsala, Sweden, SE-753 09
Actively Recruiting
12
Västmanlands Hospital
Västerås, Sweden, SE-723 35
Actively Recruiting
Research Team
M
Maria Gebre-Medhin, MD
CONTACT
I
Iréne Schönström, RN
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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