Actively Recruiting
Physical Activity Program for TRD
Led by Unity Health Toronto · Updated on 2025-04-30
30
Participants Needed
1
Research Sites
62 weeks
Total Duration
On this page
Sponsors
U
Unity Health Toronto
Lead Sponsor
U
University of Toronto
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is a pilot study examining the delivery of a remotely delivered, one-on-one, individualized physical activity (PA) program in adult participants with treatment-resistant depression (TRD).
CONDITIONS
Official Title
Physical Activity Program for TRD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 65 years who are sedentary, doing less than 60 minutes of moderate-to-vigorous physical activity per week
- Diagnosed with major depressive disorder without psychotic symptoms and currently experiencing a major depressive episode confirmed by a clinical interview
- Have a Montgomery-Åsberg Depression Rating Scale score of 7 or higher at screening
- Have not responded adequately to at least two antidepressant treatments of proper dose and duration during the current episode
- Receiving treatment that follows Canadian guidelines with no medication changes in the 28 days before screening
You will not qualify if you...
- Current symptoms of mania, hypomania, mixed episodes, or psychosis
- Diagnosis of alcohol or substance use disorder within the past 3 months
- Pregnant females
- Recent cardiovascular event within the past 12 months
- Medical conditions that contraindicate exercise based on a readiness questionnaire
- Balance, gait, or movement problems that prevent physical activity participation
- Other conditions deemed by investigators to interfere with study completion
- Exercise-induced asthma
- Use of medications like beta blockers that affect heart rate during exercise
- No ownership of a smartphone
- No reliable internet access
- Received intravenous ketamine treatment in the last 2 months
- Non-English speakers due to communication and consent requirements
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
St. Michael's Hospital, Unity Health Toronto
Toronto, Ontario, Canada
Actively Recruiting
Research Team
V
Venkat Bhat
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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