Actively Recruiting

Phase Not Applicable
Age: 18Years - 80Years
All Genders
NCT07039305

Physical Capacity Building for Chronic Stroke

Led by Medical University of South Carolina · Updated on 2025-12-08

76

Participants Needed

1

Research Sites

208 weeks

Total Duration

On this page

Sponsors

M

Medical University of South Carolina

Lead Sponsor

E

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Collaborating Sponsor

AI-Summary

What this Trial Is About

Cardiac rehabilitation is the standard-of-care treatment option for patients with cardiovascular disease and has been shown to improve many aspects critical to patient recovery. Investigators believe that individuals who have had a stroke need to be treated similarly. Investigators will study the effects of a comprehensive modified cardiac rehabilitation program to determine if it can improve some of the physical and psychosocial problems common in survivors of stroke with and without depression.

CONDITIONS

Official Title

Physical Capacity Building for Chronic Stroke

Who Can Participate

Age: 18Years - 80Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 18-80
  • Diagnosed with stroke at least 6 months before enrollment
  • Residual weakness in the lower leg with Fugl-Meyer lower extremity motor score less than 34
  • Able to walk without help and without using an ankle-foot orthosis at speeds from 0.2 to 1.0 meters per second
  • Able to follow instructions, complete cognitive tests, and communicate exertion, pain, and distress
  • No changes in antidepressant or psychotropic medication for at least 4 weeks prior (6 weeks if newly started)
  • Suicide risk scores on HDRS17 and PHQ-9 questions 3 and 9 are 2 or less
  • Able to provide informed consent
  • Depressed participants will be screened and diagnosed for major depressive disorder using standard interviews
Not Eligible

You will not qualify if you...

  • Unable to walk at least 150 feet or has intermittent claudication while walking
  • Unstable heart rhythm problems, hypertrophic cardiomyopathy, severe aortic stenosis, angina, or breathlessness at rest or during daily activities
  • Dementia
  • Life expectancy less than 1 year
  • History of deep vein thrombosis or pulmonary embolism within 6 months
  • Uncontrolled diabetes with recent weight loss, diabetic coma, or frequent insulin reactions
  • Severe high blood pressure with systolic over 200 mmHg or diastolic over 110 mmHg at rest
  • Suicide attempt in the last 2 years or assessed suicidal risk
  • Currently enrolled in another rehabilitation trial for motor, cognitive, or psychosocial recovery
  • Severe cognitive impairment with Montreal Cognitive Assessment score 15 or less
  • Moderate to severe neglect preventing cognitive testing
  • For brain stimulation procedures: presence of electronic or metal implants, history of seizures, or women of childbearing potential

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

1
2
3
+1

Trial Site Locations

Total: 1 location

1

Medical University of South Carolina

Charleston, South Carolina, United States, 29425

Actively Recruiting

Loading map...

Research Team

R

Ryan E Ross, Ph.D.

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

TREATMENT

Number of Arms

1

Not the Right Trial for You?

Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.

Already have an account? Log in here