Actively Recruiting

Phase Not Applicable
Age: 40Years - 55Years
MALE
Healthy Volunteers
NCT06240208

Physical Inactivity and Appetite Regulation

Led by Rigshospitalet, Denmark · Updated on 2026-03-30

40

Participants Needed

1

Research Sites

143 weeks

Total Duration

On this page

Sponsors

R

Rigshospitalet, Denmark

Lead Sponsor

N

Novo Nordisk A/S

Collaborating Sponsor

AI-Summary

What this Trial Is About

The goal of this parallel-group, two-arm, assessor-blinded, randomised clinical trial is to investigate the effects of reducing physical activity on food intake and satiety in physically active and healthy males, 40-55 years of age. The main questions it aims to answer are: * Does physical inactivity affect GLP-1 stimulated food intake? * Does physical inactivity affect food preferences, satiety and other mechanisms supporting appetite regulation? Participants will be randomised (1:1) to two weeks of either no intervention (control group) or inactivity. Inactivity will be implemented as cessation of active commuting and all other structured exercise. Furthermore, steps will be reduced to a maximum of 1500 steps/day. Researchers will compare the inactivity group to the control group to see if physical inactivity impairs appetite regulation.

CONDITIONS

Official Title

Physical Inactivity and Appetite Regulation

Who Can Participate

Age: 40Years - 55Years
MALE
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Male
  • Age 40 to 55 years
  • Body mass index (BMI) greater than 20 and less than 25 kg/m2
  • Physically active with active commuting by biking at least 10 km four days per week or equivalent physical activity four days per week
  • Healthy based on self-report, medical exam, and biochemical screening
  • Able to adhere to two weeks of inactivity including no running, cycling, or other exercise and limiting steps to a maximum of 1500 per day
  • Caucasian
  • No body weight change greater than 5 kg in the last 6 months
  • Eats breakfast and lunch daily
  • Does not follow specific dietary restrictions
  • No dislike of spaghetti bolognese
  • No diagnosis of psychiatric disorder or treatment with antidepressant or antipsychotic medication
  • No history of suicidal behavior or thoughts
  • No previous surgical treatment for obesity
  • No cardiovascular disease
  • No rheumatologic disease
  • No metabolic or endocrine disease
  • No liver disease (ASAT or ALAT greater than twice upper normal range)
  • No other chronic disease
  • Not an elite athlete
  • No frequent or chronic use of medications affecting body weight, physical performance, or inflammation (NSAIDs, DMARDs, corticosteroids)
  • No current infection
  • No history of cancer
  • No anemia (hematocrit less than 33%)
  • No smoking
  • No participation in other intervention research studies
Not Eligible

You will not qualify if you...

  • Clinical or biochemical signs of disease
  • HbA1c greater than 39 mmol/mol
  • Unable to commit the needed time to complete the intervention
  • Language barrier, mental incapacity, unwillingness, or inability to understand and complete the interventions

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

1
2
3
+1

Trial Site Locations

Total: 1 location

1

Copenhagen University Hospital

Copenhagen, Denmark

Actively Recruiting

Loading map...

Research Team

I

Inge Holm

CONTACT

B

Bente K Pedersen, Dr Med

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

PREVENTION

Number of Arms

2

Not the Right Trial for You?

Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.

Already have an account? Log in here