Actively Recruiting
Physical Rehabilitation for Older Patients With Acute Heart Failure With Preserved Ejection Fraction
Led by Wake Forest University Health Sciences · Updated on 2025-07-02
880
Participants Needed
1
Research Sites
254 weeks
Total Duration
On this page
Sponsors
W
Wake Forest University Health Sciences
Lead Sponsor
N
National Institute on Aging (NIA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The REHAB-HFpEF trial will determine whether a novel physical rehabilitation intervention will improve the primary outcome of combined all-cause rehospitalizations and mortality and the secondary outcome of major mobility disability during 6-month follow-up in patients hospitalized for heart failure and preserved ejection fraction (HFpEF), which is nearly unique to older persons, and for which there are few treatment options.
CONDITIONS
Official Title
Physical Rehabilitation for Older Patients With Acute Heart Failure With Preserved Ejection Fraction
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 60 years or older
- Ejection fraction of 45% or higher
- Hospitalized for more than 24 hours for acute decompensated heart failure (ADHF) or diagnosed with ADHF during hospitalization
- ADHF confirmed by physician based on symptoms, signs, and specific heart failure treatments
- Clinical stability allowing participation in study assessments and intervention
- Independent in basic activities of daily living, able to ambulate independently before admission
- Able to walk 4 meters with or without an assistive device at enrollment
You will not qualify if you...
- Acute myocardial infarction within past 3 months or planned coronary intervention within next 6 months
- Severe aortic or mitral valve stenosis
- Severe valvular heart disease with planned intervention within next 6 months
- Known pericardial constriction, genetic hypertrophic cardiomyopathy, or infiltrative cardiomyopathy including amyloid heart disease
- Planned discharge to a facility where the participant will not live independently
- Terminal illness other than heart failure with life expectancy less than 1 year
- Impairment from stroke or other medical disorders preventing participation
- Known dementia or low cognitive assessment scores without social support
- Advanced chronic kidney disease with very low kidney function or dialysis
- Regular moderate to vigorous exercise over 30 minutes at least twice weekly in past 6 weeks
- Enrollment in another clinical trial not approved for co-enrollment
- High risk for non-adherence
- Inability or unwillingness to comply with study requirements or give consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Atrium Health Wake Forest Baptist
Winston-Salem, North Carolina, United States, 27157
Actively Recruiting
Research Team
M
Michael B Nelson, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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