Actively Recruiting
Physiologic Assessment of Microvascular Function in Patients With Cardiac Amyloidosis
Led by Samsung Medical Center · Updated on 2025-03-14
30
Participants Needed
1
Research Sites
763 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aim of the study is to evaluate coronary flow reserve (CFR), index of microcirculatory resistance (IMR), and proportion of overt microvascular disease, defined as depressed CFR as well as elevated IMR in patients with cardiac amyloidosis. The second objective of this study is to compare results of non-invasive test including serum light chain amount, Doppler echocardiography with 2D strain, and cardiac perfusion MRI. The third object of this study is to evaluate the association between physiologic indices and pathologically measured percent area involvement of interstitium.
CONDITIONS
Official Title
Physiologic Assessment of Microvascular Function in Patients With Cardiac Amyloidosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 85 years
- Confirmed cardiac amyloidosis by heart biopsy
- Confirmed amyloidosis by biopsy other than heart with evidence of heart involvement on echocardiography
- Underwent invasive physiologic assessment within 3 months from primary disease diagnosis
You will not qualify if you...
- Cardiogenic shock
- Unstable vital signs preventing coronary angiography
- Major bleeding within the last 3 months
- Active bleeding
- Coagulopathy
- Severe valvular heart disease
- Refusal to provide informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Samsung Medical Center
Seoul, South Korea
Actively Recruiting
Research Team
J
Joo Myung Lee, MD, MPH, PhD
CONTACT
K
Ki Hong Choi, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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