Comparing Intraneural Facilitation Therapy and Standard Physical Therapy for Treating Type 2 Diabetic Peripheral Neuropathy in Adults Aged 45 to 85

What this Trial Is About

Researchers are investigating two treatment approaches for Peripheral Neuropathy in people with Type 2 Diabetes, a common and costly complication causing symptoms like pain, numbness, and tingling. This study aims to better understand how Intraneural Facilitation Therapy INF4 Therapy, a non-invasive manual technique, compares to standard physical therapy in improving neuropathy symptoms and underlying physiological functions. Participants will be randomly assigned to one of two groups one receiving nine 60-minute sessions of INF4 Therapy, which involves specific manual holds to improve blood flow in nerves, and the other receiving nine 60-minute sessions of standard physical therapy focused on muscle stretching, balance, and strengthening exercises. Treatments occur over 6 weeks during 11 study visits, including initial and follow-up assessments. Throughout the study, participants will undergo various tests including pain assessments, heart rate variability monitoring using the Welltory App, vascular imaging, blood oxygen and flow measurements, and blood draws to measure inflammation and blood sugar control. These evaluations occur at several visits to monitor changes and treatment effects. The study will analyze these measures to understand how each therapy impacts nerve function, blood flow, and inflammation over the 6-week period.

A Physiologic Comparison of Two Approaches to Treating Peripheral Neuropathy