Actively Recruiting
Study of How ANGPTL3 Gene Variants Affect Lipid and Glucose Metabolism in Adults
Led by University of Pennsylvania · Updated on 2025-09-10
50
Participants Needed
1
Research Sites
N/A
Total Duration
AI-Summary
What this Trial Is About
Researchers are evaluating how genetic variants of ANGPTL3 affect lipid and glucose metabolism in humans. The study aims to understand the role of this protein in these metabolic processes through detailed testing. This research involves volunteers with and without ANGPTL3 variants and includes healthy individuals as controls. Participants will undergo a series of tests including an oral fat tolerance test, lipoprotein kinetics test, and an oral glucose tolerance test. These procedures are designed to assess how ANGPTL3 variants influence lipid and glucose metabolism over the course of the study, which lasts an average of 13 weeks. During the study, participants will be monitored through these metabolic tests to measure outcomes related to lipid metabolism, glucose metabolism, and fatty acids. The research team will collect data throughout the study period to evaluate the effects of ANGPTL3 variants. Participants are expected to follow the study procedures and provide informed consent prior to participation.
CONDITIONS
Brief Title
Physiological Effects of ANGPTL3 Variants in Humans
Research Team
M
Marina Cuchel, MD, PhD
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