Actively Recruiting
Physiological Effects of ANGPTL3 Variants in Humans
Led by University of Pennsylvania · Updated on 2025-09-10
50
Participants Needed
1
Research Sites
291 weeks
Total Duration
On this page
Sponsors
U
University of Pennsylvania
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
To evaluate the role of ANGPTL3, on lipid metabolism. To explore the role of this protein on glucose metabolism.
CONDITIONS
Official Title
Physiological Effects of ANGPTL3 Variants in Humans
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Subjects aged 18 or older
- Carry genetic variants in the gene encoding ANGPTL3, or are unaffected controls matched for age, race, and gender
- Willing to follow study procedures
- Able to provide informed consent
You will not qualify if you...
- Medical or psychological conditions that may compromise safety or study participation
- Taking medications that may affect safety or study data
- Pregnant or nursing women
- History of liver disease or abnormal liver function tests (greater than 2 times upper limit of normal)
- History of kidney disease or chronic renal insufficiency (eGFR less than 60 mL/min/1.73 m2)
- Uncontrolled hypertension (greater than 160/100 mmHg)
- Uncontrolled diabetes
- Anemia (hemoglobin less than 11.0 mg/dL)
- History of non-skin cancer within the past 5 years
- Major surgery within the past 3 months
- History of any organ transplant
- History of alcohol or drug abuse
- Participation in clinical trials involving drugs affecting lipid metabolism within the past 6 weeks or longer
- Inability to comply with study procedures
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
Research Team
M
Marina Cuchel, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here