Actively Recruiting
Physiological Effects and Safety of Continuous High-frequency Oscillatory Ventilation in Mechanical Ventilation Patients
Led by Shanghai Zhongshan Hospital · Updated on 2024-11-20
30
Participants Needed
1
Research Sites
99 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Mechanical ventilation is an important treatment modality for intensive care unit (ICU) patients, but it also brings a series of problems such as ventilator-associated pneumonia, ventilator-induced lung injury, and atelectasis. Continuous High-Frequency Oscillation (CHFO )is often considered to have a protective effect on the lungs. CHFO provides effective gas exchange at supraphysiological frequencies while minimizing pressure fluctuations, producing tidal volumes smaller than dead space and adjusting around a continuously expanding pressure to optimize end-expiratory lung volume (EELV) by achieving and maintaining lung recruitment. However, the physiological effects and safety of CHFO in critically ill patients on mechanical ventilation lack relevant research. The objective of this research is to assess the feasibility, safety, and efficacy of CHFO in a population of mechanically ventilated critically ill patients.
CONDITIONS
Official Title
Physiological Effects and Safety of Continuous High-frequency Oscillatory Ventilation in Mechanical Ventilation Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients older than 18 and younger than 90 years
- Admitted to the ICU after October 15, 2024, who are intubated and expected to be unable to be extubated within 48 hours due to ARDS, atelectasis, or ventilator-associated pneumonia
- Signed informed consent for MetaNeb treatment
You will not qualify if you...
- Refusal to participate in the proposed study
- Age under 20 years
- Pregnancy
- Significant hemodynamic instability defined as an increase of more than 20% in catecholamine doses in the last hour despite blood volume optimization for a target mean blood pressure between 65 and 75 mmHg
- Participation in another trial within 30 days prior to eligibility
- Severe chronic respiratory disease requiring long-term oxygen therapy or home mechanical ventilation
- Pneumothorax
- Expected duration of mechanical ventilation less than 48 hours
- Decision to refuse life-sustaining treatment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Zhongshan Hospital, Fudan University
Shanghai, Shanghai Municipality, China, 200030
Actively Recruiting
Research Team
S
Shengyu Hao, Ph.D
CONTACT
Y
Yuxian Wang, B.S
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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