Assessing the Physiological Impact and Safety of Continuous High-Frequency Oscillatory Ventilation in Critically Ill Patients Under Mechanical Ventilation

What this Trial Is About

Researchers are evaluating the physiological effects and safety of Continuous High-Frequency Oscillation (CHFO) in critically ill patients who require mechanical ventilation. This study aims to assess how CHFO impacts lung function and other pathophysiological parameters in patients with conditions such as acute respiratory distress syndrome, atelectasis, and ventilator-associated pneumonia. The study addresses the lack of research on the safety and benefits of CHFO in such patients. Participants will receive treatment using the CHFO machine (MetaNeb system) while undergoing invasive mechanical ventilation. The treatment involves applying CHFO continuously for 10 minutes to improve lung volume and gas exchange. Before, during, and after the intervention, researchers will collect data including ventilatory parameters, heart rate, blood pressure, and arterial blood gases. The procedure also involves placing an electrical impedance tomography (EIT) belt to monitor lung volume changes. During the study, patients will be closely monitored with continuous data recording using the EIT device and regular collection of physiological measurements. The primary outcomes measured are changes in end-expiratory lung volume and chest electrical impedance tomography values at the start and end of CHFO treatment. Secondary outcomes include central venous pressure, oxygenation ratios, plateau pressure, mean arterial pressure, and adverse events. The total intervention duration is 10 minutes with data collected before, during, and 30 minutes after treatment.

Physiological Effects and Safety of Continuous High-frequency Oscillatory Ventilation in Mechanical Ventilation Patients