Physiological Responses to Heat Stress During High-risk Events

What this Trial Is About

Exertional heat stroke (EHS) is a serious condition affecting many military personnel each year, leading to potential long-lasting organ damage or death. Researchers are studying biomarkers that could help understand the risk, recovery, and safe return to duty after EHS. This observational study aims to compare soldiers who complete high-risk physical events without collapsing to those who experience EHS, to identify specific biomarkers related to heat stroke and its effects on heart, kidney, muscle, and liver function. Participants will be observed during events like ruck marches and timed runs, which are known high-risk activities for EHS. Data collection will include pre-event, post-event, and follow-up measurements such as core temperature, heart rate, and blood and urine biomarkers related to organ function. The study will monitor these markers up to 36 hours after exercise to assess physiological responses to heat stress and recovery patterns. During the study, participants will undergo various assessments including blood and urine tests every 6 hours for up to 36 hours, along with heart rate and core temperature monitoring during training. This will provide detailed information on the body's response to heat stress and help identify markers indicating successful recovery or risk. The study participation timeline includes training, immediate post-exercise monitoring, and follow-up to track changes over time.

Physiological Responses to Heat Stress During High-risk Events