Actively Recruiting
Physiology-guided vs Angiography-guided Non-culprit Lesion Complete Revascularization for Acute MI & Multivessel Disease
Led by Population Health Research Institute · Updated on 2025-06-19
5100
Participants Needed
113
Research Sites
258 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
COMPLETE-2 is a prospective, multi-centre, randomized controlled trial comparing a strategy of physiology-guided complete revascularization to angiography-guided complete revascularization in patients with acute ST-segment elevation myocardial infarction (STEMI) or non-ST-segment elevation myocardial infarction (NSTEMI) and multivessel coronary artery disease (CAD) who have undergone successful culprit lesion Percutaneous Coronary Intervention (PCI). COMPLETE-2 OCT is a large scale, prospective, multi-centre, observational, imaging study of patients with STEMI or NSTEMI and multivessel CAD in a subset of eligible COMPLETE-2 patients.
CONDITIONS
Official Title
Physiology-guided vs Angiography-guided Non-culprit Lesion Complete Revascularization for Acute MI & Multivessel Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients presenting with STEMI or type 1 NSTEMI within 72 hours of successful culprit-lesion PCI
- Residual coronary artery disease with at least one additional non-infarct-related artery stenosis amenable to PCI
- Non-culprit artery stenosis of at least 50% diameter by visual estimation
- Non-culprit artery stenosis at least 2.5 mm in diameter
- Planned complete revascularization strategy for qualifying myocardial infarction
You will not qualify if you...
- Planned or prior coronary artery bypass graft (CABG) surgery
- Inability to identify culprit lesion for STEMI or NSTEMI based on angiography, ECG, or wall motion abnormalities
- Prior PCI of a non-culprit lesion in a different vessel within 45 days before randomization
- Planned medical treatment of all qualifying non-culprit lesions without PCI
- Severe non-culprit lesion stenosis with reduced epicardial flow (TIMI flow ≤ 2) or >90% diameter stenosis
- Presence of a chronic total occlusion (CTO) if it is the only qualifying non-culprit lesion
- The only qualifying non-culprit lesion is in the same vessel territory as the culprit lesion
- MI caused by non-atherothrombotic mechanisms such as type 2 MI, spontaneous coronary artery dissection, or coronary artery embolism
- Non-cardiovascular co-morbidities with life expectancy less than 2 years
- Any medical, geographic, or social factors preventing study participation or 5-year follow-up
AI-Screening
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Trial Site Locations
Total: 113 locations
1
UCLA
Los Angeles, California, United States, 90095
Actively Recruiting
2
University of California, San Francisco
San Francisco, California, United States, 94143
Actively Recruiting
3
Cardiovascular Research Institute of Kansas
Wichita, Kansas, United States, 67226
Actively Recruiting
4
The Johns Hopkins University School of Medicine
Baltimore, Maryland, United States, 21205
Actively Recruiting
5
University of Michigan
Ann Arbor, Michigan, United States, 48109
Actively Recruiting
6
Metropolitan Cardiology Consultants / Metropolitan Heart and Vascular Institute (MCC/MHVI)
Coon Rapids, Minnesota, United States, 55433
Actively Recruiting
7
RWJ Barnabas Health
Jersey City, New Jersey, United States, 07302
Actively Recruiting
8
Bassett Medical Center
Cooperstown, New York, United States, 13326
Actively Recruiting
9
VA New York Harbor HealthCare System
New York, New York, United States, 10010
Actively Recruiting
10
NYU Grossman School of Medicine
New York, New York, United States, 10016
Actively Recruiting
11
Montefiore Medical Center
The Bronx, New York, United States, 10467
Actively Recruiting
12
Cleveland Clinic
Cleveland, Ohio, United States, 44195
Actively Recruiting
13
University of Virginia Medical Center
Charlottesville, Virginia, United States, 22903
Actively Recruiting
14
Westmead Hospital
Westmead, New South Wales, Australia
Actively Recruiting
15
Klinik Floridsdorf
Vienna, Austria
Actively Recruiting
16
McGill University Health Centre (MUHC)
Montreal, Quebec, Canada, H4A 3J1
Actively Recruiting
17
William Osler Health System
Brampton, Canada
Actively Recruiting
18
University of Alberta Hospital, Mazankowski Heart
Edmonton, Canada
Actively Recruiting
19
Hamilton Health Sciences
Hamilton, Canada
Actively Recruiting
20
Kingston Health Sciences Centre
Kingston, Canada
Actively Recruiting
21
St. Mary's General Hospital
Kitchener, Canada
Actively Recruiting
22
London Health Sciences Centre
London, Canada
Actively Recruiting
23
Centre Hospitalier de l'Universite de Montreal
Montreal, Canada
Actively Recruiting
24
Hopital du Sacre-Coeur de Montreal
Montreal, Canada
Actively Recruiting
25
Southlake Regional Health Centre
Newmarket, Canada
Actively Recruiting
26
Nova Scotia Health
Nova Scotia, Canada
Actively Recruiting
27
University of Ottawa Heart Institute
Ottawa, Canada
Actively Recruiting
28
Institut Universitaire de Cardiologie et de Pneumologie de Québec
Québec, Canada
Actively Recruiting
29
Regina General Hospital
Regina, Canada
Actively Recruiting
30
Royal University Hospital
Saskatoon, Canada
Actively Recruiting
31
Niagara Health
St. Catharines, Canada
Actively Recruiting
32
Newfoundland and Labrador Health Services
St. John's, Canada
Actively Recruiting
33
Thunder Bay Regional Health Sciences Centre
Thunder Bay, Canada
Actively Recruiting
34
St. Michael's Hospital (Unity Health Toronto)
Toronto, Canada
Actively Recruiting
35
Sunnybrook Health Sciences Centre
Toronto, Canada
Actively Recruiting
36
Ciusss McQ - Chaur
Trois-Rivières, Canada
Actively Recruiting
37
St Paul's Hospital
Vancouver, Canada
Actively Recruiting
38
Vancouver General Hospital
Vancouver, Canada
Actively Recruiting
39
St. Boniface Hospital
Winnipeg, Canada
Actively Recruiting
40
St. Anne's University Hospital
Brno, Czechia
Actively Recruiting
41
Aalborg University Hospital
Aalborg, Denmark
Actively Recruiting
42
Aarhus University Hospital
Aarhus, Denmark
Actively Recruiting
43
Rigshospitalet - Copenhagen University Hospital
Copenhagen, Denmark
Actively Recruiting
44
Helsinki University Hospital
Helsinki, Finland
Actively Recruiting
45
TAYS Sydankeskus Oy
Tampere, Finland
Actively Recruiting
46
Turku University Hospital
Turku, Finland
Actively Recruiting
47
St. Vinzenz-Hospital
Cologne, Germany
Actively Recruiting
48
Helios Amper-Klinikum
Dachau, Germany
Actively Recruiting
49
Universitatsklinikum Frankfurt
Frankfurt, Germany
Actively Recruiting
50
Marienkrankenhaus
Hamburg, Germany
Actively Recruiting
51
Schoen Klink Hamburg
Hamburg, Germany
Actively Recruiting
52
University Heart & Vascular Center Hamburg
Hamburg, Germany
Actively Recruiting
53
WKK Heide
Heide, Germany
Actively Recruiting
54
Gottsegen National Cardiovascular Center
Budapest, Hungary
Actively Recruiting
55
University of Szeged
Szeged, Hungary
Actively Recruiting
56
Lisie Hospital
Ernākulam, Kerala, India
Actively Recruiting
57
Meditrina Hospital
Kollam, Kerala, India
Actively Recruiting
58
Caritas Hospital Trust
Kottayam, Kerala, India
Actively Recruiting
59
Apollo Rajshree Hospitals
Indore, Madhya Pradesh, India
Actively Recruiting
60
Rukmani Birla Hospital
Jaipur, Rajasthan, India
Actively Recruiting
61
Apollo Hospital
Chennai, Tamil Nadu, India
Actively Recruiting
62
The Madras Medical Mission
Chennai, Tamil Nadu, India
Actively Recruiting
63
Meenakshi Mission Hospital and Research Center
Madurai, Tamil Nadu, India
Actively Recruiting
64
Medicover Hospitals
Hyderabad, India
Actively Recruiting
65
Krishna Institute of Medical Sciences
Secunderabad, India
Actively Recruiting
66
Azienda USL Toscana Sud Est
Arezzo, Italy
Actively Recruiting
67
UOC Cardiologia - Ospedale Maggiore
Bologna, Italy
Actively Recruiting
68
Azienda Ospedaliero - Universitaria di Ferrara
Ferrara, Italy
Actively Recruiting
69
Misericordia Hospital
Grosseto, Italy
Actively Recruiting
70
Azienda USL-IRCCS di Reggio Emilia, Reggio
Reggio Emilia, Italy
Actively Recruiting
71
Sant Andrea Hospital - Sapienza University
Rome, Italy
Actively Recruiting
72
Sorlandet Hospital Arendal
Kristiansand, Arendal, Norway
Actively Recruiting
73
Oslo University Hospital Ulleval
Oslo, Norway
Actively Recruiting
74
Stavanger University Hospital
Stavanger, Norway
Actively Recruiting
75
University Hospital Tromso
Tromsø, Norway
Actively Recruiting
76
Provincial Specialized Hospital
Legnica, Lower Silesian Voivodeship, Poland
Actively Recruiting
77
Miedziowym Centrum Zdrowia S.A. w Lubinie
Lubin, Lower Silesian Voivodeship, Poland
Actively Recruiting
78
Medical University of Warsaw
Warsaw, Masovian Voivodeship, Poland
Actively Recruiting
79
Institute for Cardiovascular Diseases Dedinje
Belgrade, Serbia
Actively Recruiting
80
University Clinical Center of Serbia
Belgrade, Serbia
Actively Recruiting
81
Hospital Clinico San Carlos
Madrid, Spain
Actively Recruiting
82
Hospital Ramon y Cajal
Madrid, Spain
Actively Recruiting
83
Hospital Universitario de La Princesa
Madrid, Spain
Actively Recruiting
84
Hospital Universitario La Paz
Madrid, Spain
Actively Recruiting
85
Hospital Virgen del Rocio
Seville, Spain
Actively Recruiting
86
Hospital Universitari i Politecnic La Fe
Valencia, Spain
Actively Recruiting
87
Hospital Clinico Universitario de Valladolid
Valladolid, Spain
Actively Recruiting
88
Karolinska University Hospital
Huddinge, Sweden
Actively Recruiting
89
Lanssjukhuset RYHOV
Jönköping, Sweden
Actively Recruiting
90
Karlstad Central Hospital
Karlstad, Sweden
Actively Recruiting
91
Skane University Hospital
Lund, Sweden
Actively Recruiting
92
Danderyd Hospital
Stockholm, Sweden
Actively Recruiting
93
Umeå University Hospital
Umeå, Sweden
Actively Recruiting
94
Uppsala University Hospital
Uppsala, Sweden
Actively Recruiting
95
East Kent Hospitals University NHS Foundation Trust
Ashford, United Kingdom
Actively Recruiting
96
Blackpool Teaching Hospitals
Blackpool, United Kingdom
Actively Recruiting
97
Ninewells Hospital
Dundee, United Kingdom
Actively Recruiting
98
Harefield Hospital
Harefield, United Kingdom
Actively Recruiting
99
Kettering General Hospital
Kettering, United Kingdom
Actively Recruiting
100
University Hospitals of Leicester
Leicester, United Kingdom
Actively Recruiting
101
Liverpool Heart and Chest Hospital
Liverpool, United Kingdom
Actively Recruiting
102
Barts Health NHS Trust
London, United Kingdom
Actively Recruiting
103
Imperial College Healthcare NHS Trust
London, United Kingdom
Actively Recruiting
104
Royal Free London NHS Foundation Trust
London, United Kingdom
Actively Recruiting
105
Manchester University NHS Foundation Trust
Manchester, United Kingdom
Actively Recruiting
106
The James Cook University Hospital
Middlesbrough, United Kingdom
Actively Recruiting
107
Freeman Hospital
Newcastle upon Tyne, United Kingdom
Actively Recruiting
108
Royal Berkshire Foundation NHS Trust
Reading, United Kingdom
Actively Recruiting
109
Sheffield Teaching Hospitals
Sheffield, United Kingdom
Actively Recruiting
110
East and North Hertfordshire NHS Trust
Stevenage, United Kingdom
Actively Recruiting
111
Royal Cornwall Hospitals NHS Trust
Truro, United Kingdom
Actively Recruiting
112
The Royal Wolverhampton NHS Trust
Wolverhampton, United Kingdom
Actively Recruiting
113
Worcestershire Acute Hospitals NHS Trust
Worcester, United Kingdom
Actively Recruiting
Research Team
C
COMPLETE-2 Project Office
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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