Actively Recruiting
Individualized Physiotherapy Addressing Patient-Specific Deficits in Amyotrophic Lateral Sclerosis Compared to Usual Care Physiotherapy: A Prospective, Pseudorandomized, Controlled, Interventional Study
Led by Charlotte Vogt · Updated on 2026-01-15
38
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating whether an individualized physiotherapy program tailored to each person's specific motor deficits can better support physical function compared to usual care physiotherapy in people with Amyotrophic Lateral Sclerosis (ALS). This study uses diagnostic assessments with a robotic leg press system to identify muscle function strengths and weaknesses. The aim is to develop safer and more patient-centered physiotherapy strategies for ALS patients. Participants are assigned either to an individualized physiotherapy program or to continue with the usual care physiotherapy. About two-thirds of participants receive the tailored program based on their specific functional deficits, while one-third continue standard therapy following typical clinical practice. The study follows participants over a period of 12 months. Throughout the study, participants will engage in physiotherapy sessions approximately three to five times per week, each lasting about 30 minutes. Researchers will assess physical function using tools like the ALS Functional Rating Scale-Revised (ALSFRS-R), focusing on activities such as climbing stairs at six months. The study monitors progress and outcomes to understand how different physiotherapy approaches impact ALS motor function and quality of life.
CONDITIONS
Brief Title
A Physiotherapy Intervention Study in Patients With Amyotrophic Lateral Sclerosis (ALS)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of clinically probable, probable laboratory-supported, or definite ALS according to revised El Escorial criteria or upper motor neuron only classification
- Age 18 years or older
- Ability to understand study information and provide written informed consent
- Willingness and ability to perform individualized exercise sessions about three to five times per week, each lasting approximately 30 minutes
- Individuals of all sexes and gender identities are eligible
You will not qualify if you...
- Pregnancy
- Presence of tracheostomy or continuous assisted ventilation
- Significant non-ALS pulmonary disease
- Other neurodegenerative or neuromuscular conditions that may affect assessments
- Concomitant life-threatening disease or impairments interfering with functional assessment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 6 months
Participants receive physiotherapy either as an individualized program tailored to their specific functional deficits or as usual care physiotherapy according to standard clinical practice.
Exercise sessions about three to five times per week, each lasting approximately 30 minutes
Trial Site Locations
Total: 1 location
1
ALS Clinic
Sankt Gallen, Switzerland, 9007
Actively Recruiting
Research Team
C
Charlotte Vogt
O
Oleksandra Hoptar
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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