Actively Recruiting
PIEB Compared With CEI on Breakthrough Pain in Nulliparous Women
Led by Holy Family Hospital, Nazareth, Israel · Updated on 2026-04-13
240
Participants Needed
1
Research Sites
116 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this randomized controlled trial is to examine the impact of programmed intermittent bolus epidural analgesia technique on the incidence of breakthrough pain during labor in nulliparous women compared to continuous epidural infusion. Nulliparous women will randomly be divided during labor into two groups; study group will receive mix of Bupivacaine and fentanyl once (bolus) every 60 minutes; the control group will receive continuously the same dose during an hour, until delivery.
CONDITIONS
Official Title
PIEB Compared With CEI on Breakthrough Pain in Nulliparous Women
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Nulliparous women
- Term pregnancy
- Singleton pregnancy
- Vertex (head down) fetal presentation
- Latent phase of labor with cervical dilation less than 6 cm
- Request for epidural analgesia
- Visual Analogue Scale (VAS) score greater than 40 for pain
You will not qualify if you...
- Estimated fetal weight over 4 kg
- Intrauterine fetal death
- Drug sensitivity
- Fetal anomalies
- Contraindication for epidural analgesia
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Holy Family Hospital
Nazareth, Israel
Actively Recruiting
Research Team
R
Raed Salim, MD
CONTACT
A
Asmaa Masri Esmail, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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