Actively Recruiting
Pilot of 18F-DCFPyL-PSMA PET in mCRPC Patients Receiving 117Lu-Vipivotide Tetraxetan
Led by Brigham and Women's Hospital · Updated on 2026-01-29
30
Participants Needed
2
Research Sites
139 weeks
Total Duration
On this page
Sponsors
B
Brigham and Women's Hospital
Lead Sponsor
P
Progenics Pharmaceuticals, Inc.
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this research study is to see how well an imaging test, called 18FDCFPyL prostate specific membrane antigen (PSMA) positron emission tomography (PET), can show the extent of prostate cancer when comparing to 68Ga-PSMA-11 PET/CT (another type of diagnostic scan for prostate cancer).
CONDITIONS
Official Title
Pilot of 18F-DCFPyL-PSMA PET in mCRPC Patients Receiving 117Lu-Vipivotide Tetraxetan
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histologically or cytologically confirmed prostate cancer
- Age 18 years or older
- Planned for standard-of-care 177Lu-Vipivotide Tetraxetan therapy after the 18F-DCFPyL PSMA-PET
- At least 1 PSMA-avid lesion on 68Ga-PSMA-11 PSMA-PET performed within 120 days prior to study entry
- Ability and willingness to comply with study procedures
- Prior or concurrent malignancy allowed if it does not interfere with safety or efficacy assessment
- Agreement to use adequate contraception prior to study entry and for 24 hours after the PSMA-PET scan
- Ability to understand and willingness to sign informed consent
You will not qualify if you...
- Uncontrolled illness including active infection, symptomatic heart failure, unstable angina, or cardiac arrhythmia
- Contraindications to PET/CT such as severe claustrophobia
- History of allergic reactions to compounds similar to 18F-DCFPyL
- Any condition that may confound study results or increase risk or burden to participation according to investigators
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Dana Farber Cancer Institute
Boston, Massachusetts, United States, 02115
Actively Recruiting
2
Brigham and Womens Hospital
Boston, Massachusetts, United States, 02215
Actively Recruiting
Research Team
H
Heather Jacene, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here