Actively Recruiting
Pilot CAR-T Cells Therapy for Children/Young Adults With CD19+ R/R Leukemia/Lymphoma
Led by Belarusian Research Center for Pediatric Oncology, Hematology and Immunology · Updated on 2024-08-28
10
Participants Needed
1
Research Sites
239 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to estimate the safety and the efficacy of CAR- T cells immunotherapy for children/young adults with relapsed or refractory acute lymphoblastic leukemia/lymphoma.
CONDITIONS
Official Title
Pilot CAR-T Cells Therapy for Children/Young Adults With CD19+ R/R Leukemia/Lymphoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- CD19+ relapsed or refractory lymphoblastic leukemia or lymphoma
- Karnofsky or Lansky performance scale score of 70 or higher
- Peripheral blood T-cell count greater than 150 cells/µL
- Written informed consent provided
You will not qualify if you...
- Primary immunodeficiencies or genetic syndromes
- Neurologic diseases
- Autoimmune diseases or polyallergies
- Transfusion of donor lymphocytes less than 6 weeks before CAR-T cell infusion
- Graft-versus-host disease grade 2 to 4
- Uncontrolled systemic infection
- Hypoxia with oxygen saturation below 90%
- Severe liver dysfunction with ALT or AST levels 3 times or more above age normal limits
- Renal dysfunction with serum creatinine 3 times or more above age normal limits
- Positive serology for HIV, active hepatitis B or C
- Pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Belarussian Research Center for Pediatric Oncology, Hematology and Immunology
Minsk, Minsk Oblast, Belarus, 223053
Actively Recruiting
Research Team
E
Elena Lukoyko, MD
CONTACT
A
Aleksandr Meleshko, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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