Actively Recruiting
Pilot Imaging Study of Leukemia
Led by University of Oklahoma · Updated on 2026-04-23
60
Participants Needed
3
Research Sites
323 weeks
Total Duration
On this page
Sponsors
U
University of Oklahoma
Lead Sponsor
E
Emory University
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is a prospective pilot study, the primary aim of which is to determine whether the presence of 18F FLT imaging signal uptake abnormalities correlate with clinically validated evidence of hematopoietic malignant disease (e.g. MRD, molecular, flow or histology) after immunotherapy and other treatments.
CONDITIONS
Official Title
Pilot Imaging Study of Leukemia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 4 to 80 years
- Evidence of high-risk hematopoietic malignancy with relapsed or refractory disease: acute lymphocytic leukemia, acute myeloid leukemia, ambiguous lineage leukemia, or myeloma
- Karnofsky or Lansky performance score of 50 or higher
- Agree to use contraceptive measures during the study if age appropriate
- Patient or parent/guardian capable of giving informed consent
- Ability to undergo 18F FLT imaging without sedation
- Bilirubin less than 2.5 mg/dL, AST/ALT less than 5 times the upper limit of normal, serum creatinine less than 1.0 or up to 2 times the upper limit of normal (whichever is higher)
- Pulse oximetry above 90% on room air
- Anticipated to receive immunotherapy (Arm A) or other non-immune therapies excluding bone marrow transplant (Arm B)
You will not qualify if you...
- Patients with uncontrolled infections
- Pregnancy or lactating
- History of allergy or intolerance to fluorothymidine
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 3 locations
1
Children's National Health System
Washington D.C., District of Columbia, United States, 20010
Withdrawn
2
Emory University
Atlanta, Georgia, United States, 30322
Not Yet Recruiting
3
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, United States, 73117
Actively Recruiting
Research Team
H
Heme Onc Lead Nurse
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
4
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