Actively Recruiting
A Pilot Study Examining Low Sulfur Diet as Treatment for Persistent Symptoms in Quiescent Crohn's Disease
Led by University of Michigan · Updated on 2026-01-15
20
Participants Needed
1
Research Sites
176 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this study is to learn about a low sulfur diet in patients with Crohn's disease. Study participants will be randomized to receive a low sulfur diet or usual diet for 8 weeks. Participants will work with study nutritionists and receive dietary educational materials. Participants will attend 2 in-person visits as well as 6 phone visits during the study. In addition, subjects will undergo testing, including a test to measure rectal sensation, a test to look for small intestinal bacterial overgrowth, and a test to measure leaky gut.
CONDITIONS
Official Title
A Pilot Study Examining Low Sulfur Diet as Treatment for Persistent Symptoms in Quiescent Crohn's Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Prior diagnosis of Crohn's disease based on endoscopic, radiographic, and/or histologic findings
- Quiescent Crohn's disease defined by fecal calprotectin less than 150 mcg/g stool and/or no inflammation on colonoscopy within 30 and 90 days of enrollment
- Persistent symptoms defined by abdominal pain and/or diarrhea T-scores ≥ 55 by NIH PROMIS-GI scale
You will not qualify if you...
- Prior total colectomy
- Presence of an end ileostomy or colostomy
- Changes in immunosuppressive medications within the past 4 weeks
- Use of antibiotics or probiotics within the past 4 weeks
- Active or suspected gastrointestinal stricture or stenosis
- Habitual vegetarian or vegan diet
- Unable or unwilling to follow a low sulfur diet
- Underweight with BMI < 18.5 kg/m2 or >7.5% unintentional weight loss in past 3 months
- Currently pregnant, breastfeeding, or unwilling/inability to use contraception during the study
- Agreement to not donate sperm, ova, or breast milk during the study
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of Michigan
Ann Arbor, Michigan, United States, 48109
Actively Recruiting
Research Team
A
Allen Lee, MD, MS
CONTACT
M
Merrick Bay
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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