Actively Recruiting

Phase 2
Age: 18Years +
All Genders
NCT05901519

A Pilot Study of Liver Protection Using Prednisone for Patients Receiving Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma

Led by University of Michigan Rogel Cancer Center · Updated on 2026-03-13

20

Participants Needed

1

Research Sites

128 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Patients on this study will self administer Prednisone for three days before starting Radiation Therapy (RT) and continue to take 60 mg/day during the first three fractions of RT.

CONDITIONS

Official Title

A Pilot Study of Liver Protection Using Prednisone for Patients Receiving Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Patients with hepatocellular carcinoma confirmed by biopsy or imaging criteria
  • Recovered from acute effects of prior liver-directed therapy with at least 4 weeks since last procedure
  • Performance status of 2 or better
  • Age 18 years or older
  • Have at least one of the following: ALBI score -1.81 or higher, lesion size 4 cm or more, or Child-Pugh score 7 or higher
  • Able to understand and sign informed consent approved by the Institutional Review Board
Not Eligible

You will not qualify if you...

  • Serious disease or illness that prevents radiation therapy
  • Allergy or hypersensitivity to prednisone or its components
  • Systemic fungal infection
  • Uncontrolled or chronic infections requiring antibiotics
  • Uncontrolled high blood sugar or insulin-dependent diabetes
  • Decompensated liver disease including ascites requiring paracentesis, hepatic encephalopathy, hepatorenal syndrome, or variceal hemorrhage
  • Active gastrointestinal bleeding within 30 days before enrollment

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Rogel Comprehensive Cancer Center

Ann Arbor, Michigan, United States, 48187

Actively Recruiting

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Research Team

T

Theodore Lawrence

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

TREATMENT

Number of Arms

1

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