Pilot Study of Low-Intensity Pulse-Based Neurofeedback for Photosensitivity in Veterans with Mild Traumatic Brain Injury

What this Trial Is About

This research aims to test a new neurofeedback treatment called low-intensity pulse-based transcranial electrical stimulation LIP-tES to reduce photosensitivity symptoms in Veterans who have had mild traumatic brain injury mTBI. Photosensitivity is common after brain injury and can affect daily functioning and recovery. The study also investigates brain activity changes linked to photosensitivity and LIP-tES using resting-state MRI scans to better understand the underlying causes and treatment effects. Participants will be randomly assigned to receive either 12 sessions of the LIP-tES treatment or 12 sessions of a sham treatment that mimics the procedure without actual neurofeedback pulses. These sessions will take place over 6 weeks. Some participants will have MRI scans before and after their sessions to observe brain connectivity related to photosensitivity and any changes following the intervention. During the study, participants will complete symptom assessments every two weeks, including the Utah Photophobia Symptom Impact Scale to measure photosensitivity changes. Additional evaluations will cover symptoms such as headaches, neurobehavioral issues, PTSD, mood, sleep quality, and pain. The study will also collect feedback on the treatments acceptability and recruitment process. Participation lasts about 6 weeks, with follow-up assessments and MRI scans for some individuals.

Pilot Study of Neurofeedback for Photosensitivity in Mild Traumatic Brain Injury