Actively Recruiting
A Pilot Study for Optimizing Meropenem Administration in the ICU
Led by Oslo University Hospital · Updated on 2025-04-24
50
Participants Needed
1
Research Sites
285 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Can antibiotic drugs be administered faster and make acceptable serum concentrations if we give short but multiple infusions compared to long and fewer infusions? In this study we will compare giving meropenem 1 gram 6 times daily in 15 minutes infusions to the recommended 2 gram 3 times daily in 3 hours infusions. In patients in the intensive care unit, the need for intravenous access is of essence. If 6 short infusions results in the same serum concentrations as 3 long infusions, we will increase intravenous access from 15 to 22.5 hours daily.
CONDITIONS
Official Title
A Pilot Study for Optimizing Meropenem Administration in the ICU
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients 18 years or older admitted to the ICU at Oslo University Hospital, Rikshospitalet
- Patients who will be treated with meropenem for proven or suspected serious infection
- Patients or their next of kin provide written informed consent
You will not qualify if you...
- Known allergy to beta-lactam antibiotics
- Current use of valproate medication
- Pregnancy
- Lack of consent
AI-Screening
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Trial Site Locations
Total: 1 location
1
Oslo University Hospital
Oslo, Norway, 0242
Actively Recruiting
Research Team
I
Ingvild Nordøy, PhD
CONTACT
T
Trine Kåsine, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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