Actively Recruiting
A Pilot Study of Revian Red All LED Cap as a Novel Treatment for Central Centrifugal Cicatricial Alopecia
Led by Wake Forest University Health Sciences · Updated on 2026-03-04
5
Participants Needed
1
Research Sites
13 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Central centrifugal cicatricial alopecia (CCCA) is a type of scarring hair loss mainly affecting middle-aged women of African descent. This condition causes patches of scarred scalp that grow larger over time, leading to brittle, shorter hair and symptoms like itching, pain, and tenderness. Since CCCA can cause permanent hair loss and distress, effective treatments are needed, but current options are limited and not well studied. This study evaluates the Revian Red All LED cap, a wireless device that uses two wavelengths of light (620 nm and 660 nm) once daily for 10 minutes, to see if it can reduce inflammation, stop hair loss, and encourage regrowth in people with CCCA. Five women diagnosed with CCCA will use the cap daily for six months. Photos and dermatoscope images will be taken every two months to track changes in hairline and hair growth. Participants will complete questionnaires about their hair loss symptoms at each visit. The study measures include hairline stabilization and regrowth at multiple time points over six months. The research team aims to assess if this light therapy can help manage CCCA symptoms and hair loss. The entire study lasts six months, with ongoing monitoring and symptom evaluation during that time.
CONDITIONS
Brief Title
A Pilot Study of Revian Red All LED Cap as a Novel Treatment for Central Centrifugal Cicatricial Alopecia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women aged 18 years or older with biopsy-confirmed diagnosis of CCCA Stage II-III
- On stable treatment without changes (doxycycline, topical steroids, minoxidil, or at least 8 rounds of intralesional steroids) for at least 3 months
- Recruited from outpatient dermatology clinics at Wake Forest Baptist Health Department of Dermatology
You will not qualify if you...
- Having a type of hair loss other than central centrifugal cicatricial alopecia
- Prior treatment with light-based therapy for alopecia
- Male gender due to low prevalence of CCCA in males
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person) for diagnosis confirmation and informed consent
Duration - 6 months
Participants use the Revian Red All LED cap once daily for 10 minutes as a treatment for 6 months.
Visits every 2 months for standardized and dermatoscope photos and symptom questionnaires
Trial Site Locations
Total: 1 location
1
Wake Forest School of Medicine - Dermatology Clinic
Winston-Salem, North Carolina, United States, 27157
Actively Recruiting
Research Team
I
Irma M Richardson, MHA
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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