Analgo-sedation of patients with burns outside the operating room.
Cesare Gregoretti, Daniela Decaroli, Quirino Piacevoli...
https://pubmed.ncbi.nlm.nih.gov/19016572Actively Recruiting
Early Phase 1
Age: 18Years +
All Genders
ID03695887
A Pilot Randomized Controlled Crossover Trial of Disposable Nitrous Oxide Canisters for Pain Control During Burn Dressing Changes
Led by University of Manitoba · Updated on 2026-05-14
30
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the use of disposable nitrous oxide canisters to provide better pain control during burn dressing changes. Despite advances in burn care, managing pain during routine wound care remains challenging due to the high doses of narcotics required and their potential side effects. This pilot randomized controlled crossover trial aims to test if nitrous oxide, a rapidly acting analgesic, can improve pain relief compared to placebo in adult burn patients. Participants will receive nitrous oxide inhalant or placebo canisters during burn dressing changes. Nitrous oxide acts within seconds and provides pain relief lasting minutes, making it potentially suitable for short but intense pain episodes like dressing changes. The study compares pain and anxiety levels when using nitrous oxide versus placebo, with treatments administered in a double-blinded and randomized manner. Participants will be assessed for pain and anxiety using the Burn Specific Pain Anxiety Scale and Visual Analogue Scales before, during, and after dressing changes. Researchers will also monitor the use of additional anxiolytics at these time points. The study enrolls adult burn patients with 5-20% body surface area burns and excludes those with serious respiratory or cardiovascular conditions or those unable to use the inhalant. The trial is led by the University of Manitoba and started in 2019, continuing until 2029.
CONDITIONS
Brief Title
A Pilot Trial of Disposable Nitrous Oxide Canisters in Providing Pain Control During Burn Dressing Changes
Who Can Participate
Age: 18Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Adult burn patients admitted to the Health Sciences Centre
- Total body surface area burned of 5-20%
You will not qualify if you...
- Admitted to intensive care unit
- Unable to participate in measurement outcomes due to sedation, cognitive impairment, language barrier, or visual impairment
- Medical conditions preventing nitrous oxide use, including respiratory disease and significant cardiovascular disease
- Pregnant
- Physically unable to hold the canister
- Oxygen saturation below 90% on room air
- Face burn
- Pre-injury narcotics use (relative exclusion)
- Use of intravenous ketamine
- Pre-existing lung injury
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Treatment
Duration - During the period of burn dressing changes
Participants receive either nitrous oxide or placebo during burn dressing changes to evaluate pain control effectiveness in a randomized crossover design.
Visits during each dressing change when treatments are administered
Trial Site Locations
Total: 1 location
1
University of Manitoba
Winnipeg, Manitoba, Canada, R3A 1R9
Actively Recruiting
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Research Team
S
Sarvesh Logsetty, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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Published Research Related To This Trial
Analgesia effect of a fixed nitrous oxide/oxygen mixture on burn dressing pain: study protocol for a randomized controlled trial.
Li Yuxiang, Tang Lu, Yu Jianqiang...
https://pubmed.ncbi.nlm.nih.gov/22624697[Analgesic and sedative effects of inhaling a mixture of nitrous oxide and oxygen on burn patient during and after dressing change].
Yu-xiang Li, Hong-tai Tang, Wan-fang Zhou...
https://pubmed.ncbi.nlm.nih.gov/24495641The abbreviated burn specific pain anxiety scale: a multicenter study.
L A Taal, A W Faber, N E van Loey...
https://pubmed.ncbi.nlm.nih.gov/10498356Nitrous oxide and the inhalation anesthetics.
Daniel E Becker, Morton Rosenberg
https://pubmed.ncbi.nlm.nih.gov/19108597