Actively Recruiting

Early Phase 1
Age: 18Years +
All Genders
NCT05702398

Pilot Trial of Supplemental Vitamin A and Nicotinamide

Led by Rhode Island Hospital · Updated on 2026-03-20

30

Participants Needed

1

Research Sites

256 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The goal of this clinical trial is to assess the feasibility and safety of oral nicotinamide (NAM; a derivative of vitamin B3 \[niacin\]) and vitamin A in a high-risk population of kidney transplant recipients with a history of skin cancer to generate preliminary data for future cancer prevention clinical trials.

CONDITIONS

Official Title

Pilot Trial of Supplemental Vitamin A and Nicotinamide

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • 18 years old or greater
  • History of 2 or more confirmed invasive cutaneous squamous cell carcinomas in the past 2 years or at least one billed treatment code for destruction of 15 or more benign or premalignant skin lesions
  • Able to understand, read, and write English proficiently
Not Eligible

You will not qualify if you...

  • Liver disease
  • Active peptic ulcer disease
  • Recent myocardial infarction
  • Low blood pressure (hypotension)
  • Internal cancer within the past 5 years
  • Severe kidney impairment with eGFR less than 15 mL/min/1.73 m2
  • Unable to follow up due to social reasons
  • Genetic skin cancer syndromes such as Gorlin's syndrome
  • Large number of current skin cancers
  • Metastatic squamous cell carcinoma or invasive melanoma within the past 5 years
  • Pregnancy or lactation
  • Need for ongoing carbamazepine use
  • Use of acitretin or other oral retinoids in the past 6 months
  • Use of supplemental nicotinamide, niacin, vitamin A, or beta carotene in the past 6 months
  • Field treatment for actinic keratoses within the previous 4 weeks
  • Use of topical steroids

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Rhode Island Hospital

Providence, Rhode Island, United States, 02912

Actively Recruiting

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Research Team

E

Eunyoung Cho, ScD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

QUADRUPLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

BASIC_SCIENCE

Number of Arms

2

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