Actively Recruiting
Pinoxin for the Prevention of Radiation-Induced Skin Injury
Led by Fudan University · Updated on 2026-04-22
202
Participants Needed
2
Research Sites
121 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The incidence of radiation-induced skin injury is high, and effective preventive measures are currently lacking. This study evaluates the role of the skin protective agent Pinoxin in preventing skin injury. Patients are randomly assigned into two prospective groups: treatment group and control group. In treatment group, patients will receive Pinoxin treatment. In control group，patients will receive placebo treatment. The rate of grade 2 or greater skin injury will be analyzed.
CONDITIONS
Official Title
Pinoxin for the Prevention of Radiation-Induced Skin Injury
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age ≥ 18 years, regardless of gender.
- Pathologically diagnosed with a malignant tumor.
- Scheduled to receive long-course radiotherapy with a total dose of ≥50 Gy, in accordance with standard treatment guidelines.
- No prior history of radiotherapy.
- Has provided signed and dated informed consent, indicating that the patient has been informed of all relevant aspects of the study.
- Patients who are willing and able to comply with scheduled visits, treatment plans, laboratory tests, and other study procedures.
You will not qualify if you...
- History of dermatologic conditions (e.g., vitiligo, psoriasis, etc.) or collagen vascular diseases.
- Planned hypofractionated radiotherapy regimen.
- Recent use (e.g., within 3 months) of similar topical protective agents.
- Known hypersensitivity to any related components or materials.
- Immunodeficiency disorders.
- Women who are pregnant or lactating.
- Any other condition that, in the investigator's judgment, may compromise patient safety or protocol compliance. This includes severe concomitant illnesses (including psychiatric disorders) requiring active treatment, significant laboratory abnormalities, or significant social/familial factors.
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Fudan University Shanghai Cancer Center
Shanghai, Shanghai Municipality, China, 200032
Actively Recruiting
2
Fudan University Shanghai Cancer Center
Shanghai, China
Actively Recruiting
Research Team
Z
Zhen Zhang, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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