Actively Recruiting
Pistachio Snacking and Metabolic Flexibility
Led by University of South Carolina · Updated on 2026-01-14
60
Participants Needed
1
Research Sites
69 weeks
Total Duration
On this page
Sponsors
U
University of South Carolina
Lead Sponsor
A
American Pistachio Growers
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to evaluate the effects of pistachio snacking on metabolic flexibility (at rest, during exercise, and in post-exercise recovery) in healthy overweight and obese adults. Secondary goals include evaluating effects on changes in diet quality, sleep characteristics, physical activity, and hormonal health in women. In randomized order, participants will complete four days of pistachio snacking and four days of normal dietary habits (control). For both conditions, primary outcomes of resting substrate metabolism, metabolic flexibility during exercise, and post-exercise substrate metabolism will be measured pre-post intervention via indirect calorimetry. Secondary outcome of diet quality (kcal, carb, fat, protein) will be measured pre-post intervention via diet log. Exploratory outcomes of daily physical activity (steps, intensity), nightly sleep characteristics (quantity, quality, latency, efficiency), and daytime sleepiness and hunger.
CONDITIONS
Official Title
Pistachio Snacking and Metabolic Flexibility
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Males and females
- Age between 25 and 45 years
- Overweight or obese with BMI between 25.0 and 34.9 kg/m²
- Poor sleep quality with a Pittsburgh Sleep Quality Index of 5 or higher
- Healthy with no diagnosed metabolic, cardiovascular, sleep, or other health conditions affecting metabolism or exercise ability
- Not meeting weekly physical activity guidelines (less than 150 minutes moderate, less than 75 minutes vigorous, and less than 2 days strength training)
- Not following a restrictive diet or eliminating certain food groups
You will not qualify if you...
- Allergies to nuts, especially tree nuts
- Having a pacemaker
- Following a restrictive diet or eliminating certain food groups
- Known metabolic or endocrine disorders such as prediabetes, diabetes, or polycystic ovary syndrome
- Cardiovascular, neuromuscular, or musculoskeletal disorders
- Current or recent cancer or cancer treatment within the past year
- History of gastrointestinal surgery or hysterectomy
- For women: pregnant, planning pregnancy, pregnant within the last year, breastfeeding, or perimenopausal
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Public Health Research Center: Clinical Exercise Research Center
Columbia, South Carolina, United States, 29208
Actively Recruiting
Research Team
C
Callie Unrein, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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