Actively Recruiting
PIVKA-II for Predicting Portal Vein Thrombosis in Hepatocellular Carcinoma
Led by Tanta University · Updated on 2025-05-07
116
Participants Needed
1
Research Sites
50 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this cross-sectional observational study is to evaluate the relation between Prothrombin induced by vitamin K absence II (PIVKA-II) and the presence of portal vein tumor thrombosis (PVTT) in hepatocellular carcinoma (HCC) patients. Researchers will compare PIVKA-II serum levels in HCC patients with PVTT and without PVTT. Participants will undergo history-taking, clinical examination, laboratory investigations, PIVKA-II serum level, Child-Pugh classification, Model for End-stage Liver Disease (MELD) score, BCLC staging, abdominal ultrasonography, and Triphasic CT abdomen with contrast or MRI to evaluate tumor site, size, number, and presence of PVTT (a filling defect in the portal vein or its branch to distinguish PVTT or thrombus).
CONDITIONS
Official Title
PIVKA-II for Predicting Portal Vein Thrombosis in Hepatocellular Carcinoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female patients older than 18 years
- Confirmed diagnosis of hepatocellular carcinoma (HCC) with or without portal vein tumor thrombosis (PVTT) diagnosed by two imaging tests or one imaging test with elevated serum alpha fetoprotein or liver biopsy
You will not qualify if you...
- Prior locoregional therapy or liver transplantation
- Use of vitamin K, vitamin K antagonists, or antibiotics
- Presence of cholestasis
- Renal insufficiency
- Other malignancies
- Unwillingness to participate in the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Tanta University Hospitals
Tanta, Gharbyea, Egypt, 31516
Actively Recruiting
Research Team
R
Rania M Elkafoury, MD
CONTACT
N
Nabila A Elgazzar, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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