Actively Recruiting
Place of Nasogastric Tube in Uncomplicated Adhesive Small Bowel Obstruction
Led by Centre Hospitalier Universitaire, Amiens · Updated on 2024-05-16
504
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
Sponsors
C
Centre Hospitalier Universitaire, Amiens
Lead Sponsor
C
Centre Hospitalier de Beauvais
Collaborating Sponsor
AI-Summary
What this Trial Is About
Acute adhesive Small Bowel Obstruction (ASBO) is a public health issue: this is the 3rd cause of hospitalization in Digestive Surgery Departments, 20-30% of patients will be operated, the mortality rate per episode is 3%, the duration of hospitalization is 8 days (up to 16 if resection), and it is associated with a tremendous health care expenses. The working group on ASBO of the World Society of Emergency Surgery suggested two distinct approaches for the management of acute ASBO: non-operative management (NOM) which concerning around 85% of patients and operative management (OM) : * OM: if there is clinical signs of strangulation, peritonitis, bowel ischemia, or if IV CT Scan shows sign of ischemia, strangulation, peritonitis, or if the occlusion persists for more than 72 hours; * NOM in all other cases, including nasogastric tube (NGT), intravenous administration of fluids, and clinical and biochemical monitoring for 72h. NGT is an old concept first describe for treatment of ASBO based on several studies made on the dog where he proved efficacy of NGT by aspirating gas in the stomach favorising venous decompression and survival of patients. Since, NGT became one of the pillars of NOM. However NGT is quite bad tolerated by patients (ranked the most painful hospital procedure), some of them refuse it, others put off after the beginning of the treatment and one of the most frequent complications of NGT is pneumonia, which is quite surprising when the first argument for its insertion is to avoid inhalation pneumonia. Four specific retrospectives studies showed that absence of NGT is possible in 20 to 80% of included patients and was associated with a decrease: in transit recovery time; in complications rate (including rates of pneumonia); in length of stay (LOS); without an increased risk of surgery or resection. 20-87% (a total of 922 patients) were managed successfully conservatively without NGT with a reduction LOS of 2-6 days compared with NGT. But none of this series focused on the patient relief as an endpoint. A retrospective critical analysis of our own management (January - December 2019, n=96) found that: only 17% of patients had a NGT during the IV CTscan, the presence of the NGT did not influence neither gastric volume nor the rate of full stomach, and gastric volume did not influence patient management. To summarize, the investigators therefore know that the insertion of a NGT is painful, does not relieve all patients, and has an unquantified therapeutic effect on the evolution of ASBO. That is why it is pertinent, in 2023, to question the useless of NGT in the treatment of ASBO, in selected patients. This study would be the first randomized controlled trial to focus on the absence of NGT for the NOM of patients with ASBO. The results of this study could lead to a change in the surgical practice. The absence of NGT in ASBO management appears to be an innovative practice, in rupture with the current practice. This is a part of the simplification of patients'care suffering from ASBO.
CONDITIONS
Official Title
Place of Nasogastric Tube in Uncomplicated Adhesive Small Bowel Obstruction
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Presence of obstruction believed caused by adhesions (abdominal pain and distention, nausea and/or vomiting, no gas or stool)
- Uncomplicated presentation without signs of strangulation or peritonitis
- IV CT scan confirming uncomplicated ASBO
- Age 18 years or older
- Written informed consent provided
- Covered by French national health insurance
You will not qualify if you...
- Incarcerated or strangulated incisional hernia or colonic obstruction
- No previous abdominal surgery
- Obstruction occurring within 4 weeks after recent surgery
- Active gastrointestinal cancer
- Active inflammatory bowel disease
- Abdominal radiotherapy in last 6 months
- Contraindication to IV contrast for CT scan or risk factors for pneumonitis
- History of aspiration pneumonia
- Older than 85 years
- Orientation disturbances
- Bedridden status
- Chronic cerebrovascular disease or Parkinson's disease
- Dementia
- Gastroesophageal disorders such as reflux
- Pregnancy or breastfeeding
- Legal incapacity or under judicial protection
- Unable to provide informed consent
- Younger than 18 years
AI-Screening
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Trial Site Locations
Total: 1 location
1
Amiens Universitary Hospital
Amiens, France
Actively Recruiting
Research Team
J
Jean Marc Regimbeau, Pr
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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