Actively Recruiting
Placement of Antibiotic Powder in Wounds During the Emergency Room
Led by The University of Texas Health Science Center at San Antonio · Updated on 2025-08-01
200
Participants Needed
2
Research Sites
351 weeks
Total Duration
On this page
Sponsors
T
The University of Texas Health Science Center at San Antonio
Lead Sponsor
U
United States Army Institute of Surgical Research
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is the first prospective controlled study to determine whether the topical application of vancomycin powder reduces infection-related complications when applied to open fracture injuries in the acute emergency department setting.
CONDITIONS
Official Title
Placement of Antibiotic Powder in Wounds During the Emergency Room
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Subject or Legal Authorized Representative (LAR) is willing and able to provide written informed consent.
- Adult 18 years of age or older.
- Open fracture of the humerus, radius, ulna, femur, tibia, and/or fibula.
- 24 hours or less has elapsed from the estimated time of injury to study intervention.
You will not qualify if you...
- Time from injury greater than 24 hours.
- Subjects who have received acute operative care (e.g., washout in the operating room or fixation) of the open fracture at an outside facility.
- Subject or LAR speaks neither English nor Spanish.
- High-potency antibiotic powder or solution applied to the wound prior to enrollment; simple ointment or antibiotic-impregnated dressings allowed.
- Documented allergies or serious reactions to vancomycin; history of uncomplicated "red man syndrome" not exclusionary.
- Pregnant subjects; females of childbearing potential will have pregnancy testing if pregnancy is suspected.
- Prisoners.
- Participation in other clinical research involving investigational antimicrobial products within 30 days of randomization.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
University Hospital
San Antonio, Texas, United States, 78229
Actively Recruiting
2
San Antonio Military Medical Center
San Antonio, Texas, United States, 78234
Not Yet Recruiting
Research Team
R
Robert A De Lorenzo, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
3
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