Actively Recruiting

Phase Not Applicable
Age: 55Years +
All Genders
NCT07429136

Plant-based Protein-rich Weight Loss Intervention in 55+ Adults With Obesity

Led by Amsterdam University of Applied Sciences · Updated on 2026-02-24

200

Participants Needed

1

Research Sites

137 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The objective of the 2EAT RCT is to investigate whether a shift towards more plant-based (≥60% with a minimum of 50%) protein intake can be achieved in an energy restricted diet for three and six months in older adults (55+) with obesity. The 2EAT researchers developed a new dietary counseling plan for six months. This includes four individual consultations, five group meetings and three 24h-recalls. In these six months, participants receive dietary counseling focused on energy restriction (-500 kcal), higher protein intake (aim towards 1.2 g/kg/d, minimum of 0.8 g/kg/d). Participants are randomly allocated either to the more plant-based diet (≥60%) or the more animal-based diet (≥60%). At the start of the intervention, participants are provided with a workbook and recipe book. Secondary objectives are to assess the effect after three and six months 2EAT dietary treatment on 1) weight loss and 2) skeletal muscle mass. Exploratory objectives are to assess the effect after three and six months 2EAT dietary treatment on 1) physical health outcomes (muscle mass and physical performance), 2) body composition, 3) metabolic blood parameters, 4) vitality and quality of life, 5) nutritional intake, 6) behavioral changes, 7) evaluate the process of the dietary treatment.

CONDITIONS

Official Title

Plant-based Protein-rich Weight Loss Intervention in 55+ Adults With Obesity

Who Can Participate

Age: 55Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Aged 55 or older
  • Obese with BMI >30 kg/m2 or BMI >27 kg/m2 and waist circumference >88 cm (women) or >102 cm (men)
  • Living independently (not in a health facility)
  • Willingness to notify the general practitioner about study participation
  • Written informed consent
  • Willingness to follow the study protocol
  • Consent from the study physician
Not Eligible

You will not qualify if you...

  • Unable to understand the Dutch language
  • Cognitive impairment with MMSE score less than 15
  • Receiving total or partial parenteral nutrition (TPN)
  • Alcohol or drug abuse as judged by the investigator
  • Currently enrolled in a fixed rehabilitation program or other intervention studies
  • Receiving palliative treatment or life expectancy of 3 months or less
  • Following a 100% plant-based vegetarian or vegan diet
  • Previous bariatric surgery
  • Active medical treatments that interfere with this study (e.g., weight loss medication like Ozempic, systemic or immune cancer therapies)
  • Physical disabilities preventing meeting general daily exercise guidelines for adults
  • Planning a holiday during the study period preventing attendance at group or individual sessions for more than 3 weeks
  • Diagnosed with unstable coronary heart disease, decompensated heart failure, uncontrolled hypertension or arrhythmias (e.g., NYHA class >3 heart failure)
  • Diagnosed degenerative neurocognitive disorders
  • Diagnosed renal failure
  • COPD GOLD stage greater than 3

AI-Screening

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Trial Site Locations

Total: 1 location

1

Hogeschool van Amsterdam

Amsterdam, South Holland, Netherlands, 1067SM

Actively Recruiting

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Research Team

S

Susanne Wildemast

CONTACT

S

Sjors Verlaan

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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